Cancer Causes & Control

, Volume 21, Issue 9, pp 1427–1435

Cancer risks from betel quid chewing beyond oral cancer: a multiple-site carcinogen when acting with smoking

Authors

    • Division of Health Policy Research and Development, Institute of Population Health SciencesNational Health Research Institutes
    • China Medical University Hospital
  • Min Kuang Tsai
    • Division of Health Policy Research and Development, Institute of Population Health SciencesNational Health Research Institutes
  • Wen Shen Isabella Chung
    • Division of Health Policy Research and Development, Institute of Population Health SciencesNational Health Research Institutes
  • Hui Ling Hsu
    • Division of Health Policy Research and Development, Institute of Population Health SciencesNational Health Research Institutes
  • Yen Chen Chang
    • Division of Health Policy Research and Development, Institute of Population Health SciencesNational Health Research Institutes
  • Hui Ting Chan
    • Division of Health Policy Research and Development, Institute of Population Health SciencesNational Health Research Institutes
  • Po Huang Chiang
    • Division of Health Policy Research and Development, Institute of Population Health SciencesNational Health Research Institutes
  • Ting-Yuan David Cheng
    • Department of Epidemiology, School of Public HealthUniversity of Washington
  • Shan Pou Tsai
    • University of Texas School of Public Health
Original paper

DOI: 10.1007/s10552-010-9570-1

Cite this article as:
Wen, C.P., Tsai, M.K., Chung, W.S.I. et al. Cancer Causes Control (2010) 21: 1427. doi:10.1007/s10552-010-9570-1

Abstract

Objectives

This cohort study is to assess the extent of cancer risks of betel quid chewing (without tobacco added) beyond oral cancer, as such information was limited from case–control studies.

Methods

The cohort, selected from participants in a medical screening program since 1994, consisted of 177,271 adult men with 19.2% chewers of betel quid. As of 2006, out of 4,840 deaths, 1,901 cancer deaths were identified. Mortality hazard ratios (HR) were estimated by Cox proportional hazard model. Life expectancy was calculated by life table method.

Results

One-third of smokers chewed (33%) but most of chewers smoked (90%). Risk for all cancer doubled among chewers (HR = 2.00). Risks of at least six cancer sites were increased among chewers: oral cavity (HR = 12.52), esophagus (HR = 5.64), liver (HR = 2.27), pancreas (HR = 2.67), larynx (HR = 6.24), and lung (HR = 2.43) with risks increased with increasing betel quid amount consumed. All-cancer age-adjusted mortality rates in Taiwan increased 25%, including 223% increase in oral cancer, during the last 20 years when chewing rate increased five- to tenfolds. Chewing on top of smoking increased the risks synergistically, and these two were responsible for at least half (50%) of all cancer deaths among 2 million chewers in Taiwan. Life expectancy of chewers was shorter than non-chewers by 5.93 years at age 20 and 5.55 years at age 40.

Conclusion

In addition to oral cancer, significant increases were seen among chewers for cancer of the esophagus, liver, pancreas, larynx, lung, and all cancer. Chewing and smoking, as combined by most chewers, interacted synergistically and was responsible for half of all cancer deaths in this group. They were responsible for the recent increases in oral, esophageal, pancreatic, and liver cancer in Taiwan. Chewing and smoking shortened their life span by nearly 6 years.

Keywords

Betel quid Smoking Cancer Mortality Taiwan

Copyright information

© Springer Science+Business Media B.V. 2010