Cancer Causes & Control

, Volume 21, Issue 9, pp 1397–1405

Time trends in pharyngeal cancer incidence in Norway 1981–2005: a subsite analysis based on a reabstraction and recoding of registered cases

Original paper

DOI: 10.1007/s10552-010-9567-9

Cite this article as:
Mork, J., Møller, B., Dahl, T. et al. Cancer Causes Control (2010) 21: 1397. doi:10.1007/s10552-010-9567-9

Abstract

Objective

Incidence rates of oropharyngeal squamous cell carcinoma (SCC) have been reported to be increasing in several countries in recent decades, contrasting with trends of SCCs diagnosed in neighboring anatomical sites. We investigated whether changes in classification systems and/or coding/registration practices might explain the trends in Norway, focusing on changes in oropharyngeal cancer.

Methods

Trends in cancers of the oropharynx, base of tongue, nasopharynx, hypopharynx were graphically presented for the period 1981–2005, before and after recoding. Age-period-cohort and future prediction models were fitted to oropharyngeal SCC incidence.

Results

A total of 85 (3.7%) of the 2315 pharyngeal cancers required recoding. Rates of oropharyngeal cancer in Norway were consistently two to three times higher in men, with rapid increases in both men (5% per annum) and women (4.2% per annum). Assuming generational effects, male cohorts born 1915–1950 were at increasingly higher risk of the disease. The number of oropharyngeal cancer cases is expected to double in Norway by 2020.

Conclusions

The trends were not considered materially biased by potential artefacts. The increasingly higher proportion of oropharyngeal SCC cancers is more likely explained by other factors, including an increasing high-risk HPV prevalence among recent cohorts. These results will likely have consequences on treatment and health care provision in the near future.

Keywords

Pharyngeal cancer Oropharyngeal cancer Incidence Norway Birth cohorts HPV 

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Jon Mork
    • 1
    • 2
  • Bjørn Møller
    • 2
  • Tove Dahl
    • 2
  • Freddie Bray
    • 2
    • 3
  1. 1.Department of OtorhinolaryngologyOslo University Hospital RikshospitaletOsloNorway
  2. 2.Department of Clinical and Registry-based Research, Cancer Registry of NorwayInstitute of Population-based Cancer ResearchOsloNorway
  3. 3.Department of Biostatistics, Institute of Basic Medical SciencesUniversity of OsloOsloNorway

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