Body mass index, effect modifiers, and risk of pancreatic cancer: a pooled study of seven prospective cohorts
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- Jiao, L., Berrington de Gonzalez, A., Hartge, P. et al. Cancer Causes Control (2010) 21: 1305. doi:10.1007/s10552-010-9558-x
To investigate whether the positive association of body mass index (BMI, kg/m2) with risk of pancreatic cancer is modified by age, sex, smoking status, physical activity, and history of diabetes.
In a pooled analysis of primary data of seven prospective cohorts including 458,070 men and 485,689 women, we identified 2,454 patients with incident pancreatic cancer during an average 6.9 years of follow-up. Cox proportional hazard regression models were used in data analysis.
In a random-effects meta-analysis, for every 5 kg/m2 increment in BMI, the summary relative risk (RR) was 1.06 (95% confidence interval (CI) 0.99–1.13) for men and 1.12 (95% CI 1.05–1.19) for women. The aggregate analysis showed that compared with normal weight (BMI: 18.5 to <25), the adjusted RR was 1.13 (95% CI 1.03–1.23) for overweight (BMI: 25 to <30) and 1.19 (95% CI 1.05–1.35) for obesity class I (BMI: 30 to <35). Tests of interactions of BMI effects by other risk factors were not statistically significant. Every 5 kg/m2 increment in BMI was associated with an increased risk of pancreatic cancer among never and former smokers, but not among current smokers (P-interaction = 0.08).
The present evidence suggests that a high BMI is an independent risk factor of pancreatic cancer.
KeywordsPancreatic cancerBody mass indexPooled analysisProspective cohortEffect modification
National Institutes of Health-AARP Diet and Health Study
Agricultural Health Study
Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study
Breast Cancer Detection Demonstration Project
Body mass index
National Cancer Institute-Division of Cancer Epidemiology and Genetics
Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
Shanghai Women’s Health Study
United States Radiologic Technologists Study