Original paper

Cancer Causes & Control

, Volume 21, Issue 7, pp 1025-1032

First online:

History of diabetes mellitus and the risk of prostate cancer: the Ohsaki Cohort Study

  • Qiang LiAffiliated withDivision of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of MedicineDivision of Epidemiology and Biostatistics, Department of Public Health, Xi’an Jiaotong University School of Medicine Email author 
  • , Shinichi KuriyamaAffiliated withDivision of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine
  • , Masako KakizakiAffiliated withDivision of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine
  • , Hong YanAffiliated withDivision of Epidemiology and Biostatistics, Department of Public Health, Xi’an Jiaotong University School of Medicine
  • , Toshimasa SoneAffiliated withDivision of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine
  • , Masato NagaiAffiliated withDivision of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine
  • , Yumi SugawaraAffiliated withDivision of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine
  • , Kaori Ohmori-MatsudaAffiliated withDivision of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine
  • , Atsushi HozawaAffiliated withDivision of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine
    • , Yoshikazu NishinoAffiliated withDivision of Epidemiology, Miyagi Cancer Center Research Institute
    • , Ichiro TsujiAffiliated withDivision of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine

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Abstract

Objective

The association between diabetes mellitus and the risk of prostate cancer has been tested in previous prospective cohort studies in western populations. However, no evidence from cohort studies is available for Asian populations, whose lifestyle is very different from that of westerners.

Methods

The authors examined the relationship between diabetes mellitus and the risk of prostate cancer in the Ohsaki cohort followed from 1995 to 2003, in which 230 new cases of prostate cancer were identified among 22,458 Japanese men. Baseline information including diabetes mellitus status was collected using a self-administered questionnaire. The Cox proportional hazards regression model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

Results

Although a history of diabetes mellitus was not associated with the risk of total prostate cancer in this population, after stratification based on the clinical stage of prostate cancer, patients with diabetes mellitus showed a higher risk of advanced prostate cancer with a multivariate adjusted HR = 1.89 (95% CI: 1.02–3.50). The relationship remained robust when we excluded from the analysis cases arising in the first 2 years.

Conclusion

This population-based prospective cohort study indicates that a history of diabetes mellitus is associated with an increased incidence of advanced prostate cancer.

Keywords

Diabetes mellitus Japan Prospective studies Prostatic neoplasms Incidence