Cancer Causes & Control

, Volume 21, Issue 7, pp 1025–1032

History of diabetes mellitus and the risk of prostate cancer: the Ohsaki Cohort Study

Authors

    • Division of Epidemiology, Department of Public Health and Forensic MedicineTohoku University Graduate School of Medicine
    • Division of Epidemiology and Biostatistics, Department of Public HealthXi’an Jiaotong University School of Medicine
  • Shinichi Kuriyama
    • Division of Epidemiology, Department of Public Health and Forensic MedicineTohoku University Graduate School of Medicine
  • Masako Kakizaki
    • Division of Epidemiology, Department of Public Health and Forensic MedicineTohoku University Graduate School of Medicine
  • Hong Yan
    • Division of Epidemiology and Biostatistics, Department of Public HealthXi’an Jiaotong University School of Medicine
  • Toshimasa Sone
    • Division of Epidemiology, Department of Public Health and Forensic MedicineTohoku University Graduate School of Medicine
  • Masato Nagai
    • Division of Epidemiology, Department of Public Health and Forensic MedicineTohoku University Graduate School of Medicine
  • Yumi Sugawara
    • Division of Epidemiology, Department of Public Health and Forensic MedicineTohoku University Graduate School of Medicine
  • Kaori Ohmori-Matsuda
    • Division of Epidemiology, Department of Public Health and Forensic MedicineTohoku University Graduate School of Medicine
  • Atsushi Hozawa
    • Division of Epidemiology, Department of Public Health and Forensic MedicineTohoku University Graduate School of Medicine
  • Yoshikazu Nishino
    • Division of EpidemiologyMiyagi Cancer Center Research Institute
  • Ichiro Tsuji
    • Division of Epidemiology, Department of Public Health and Forensic MedicineTohoku University Graduate School of Medicine
Original paper

DOI: 10.1007/s10552-010-9530-9

Cite this article as:
Li, Q., Kuriyama, S., Kakizaki, M. et al. Cancer Causes Control (2010) 21: 1025. doi:10.1007/s10552-010-9530-9

Abstract

Objective

The association between diabetes mellitus and the risk of prostate cancer has been tested in previous prospective cohort studies in western populations. However, no evidence from cohort studies is available for Asian populations, whose lifestyle is very different from that of westerners.

Methods

The authors examined the relationship between diabetes mellitus and the risk of prostate cancer in the Ohsaki cohort followed from 1995 to 2003, in which 230 new cases of prostate cancer were identified among 22,458 Japanese men. Baseline information including diabetes mellitus status was collected using a self-administered questionnaire. The Cox proportional hazards regression model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

Results

Although a history of diabetes mellitus was not associated with the risk of total prostate cancer in this population, after stratification based on the clinical stage of prostate cancer, patients with diabetes mellitus showed a higher risk of advanced prostate cancer with a multivariate adjusted HR = 1.89 (95% CI: 1.02–3.50). The relationship remained robust when we excluded from the analysis cases arising in the first 2 years.

Conclusion

This population-based prospective cohort study indicates that a history of diabetes mellitus is associated with an increased incidence of advanced prostate cancer.

Keywords

Diabetes mellitusJapanProspective studiesProstatic neoplasmsIncidence

Abbreviations

BMI

Body mass index.

CI

Confidence interval.

HR

Hazard ratio

NHI

National health insurance

PSA

Prostate specific antigen

Copyright information

© Springer Science+Business Media B.V. 2010