Cancer Causes & Control

, Volume 21, Issue 5, pp 657–669

Prospective study of physical activity and risk of primary adenocarcinomas of the oesophagus and stomach in the EPIC (European Prospective Investigation into Cancer and nutrition) cohort

Authors

    • CIBER Epidemiología y Salud Pública (CIBERESP)
    • Epidemiology DepartmentRegional Council of Health and Consumer Affairs
    • Servicio de Epidemiología, Consejería Sanidad y Consumo
  • Carmen Navarro
    • CIBER Epidemiología y Salud Pública (CIBERESP)
    • Epidemiology DepartmentRegional Council of Health and Consumer Affairs
  • María-Dolores Chirlaque
    • CIBER Epidemiología y Salud Pública (CIBERESP)
    • Epidemiology DepartmentRegional Council of Health and Consumer Affairs
  • María-José Tormo
    • CIBER Epidemiología y Salud Pública (CIBERESP)
    • Epidemiology DepartmentRegional Council of Health and Consumer Affairs
  • Karen Steindorf
    • Unit of Environmental EpidemiologyGerman Cancer Research Center
  • Genevieve Buckland
    • Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgrammeCatalan Institute of Oncology
  • Fátima Carneiro
    • Institute of Molecular Pathology and Immunology of the University of Porto and Medical Faculty
  • Nina Føns Johnsen
    • Institute of Cancer EpidemiologyDanish Cancer Society
  • Kim Overvad
    • Department of Cardiology, Aalborg HospitalAarhus University Hospital
    • Department of Clinical Epidemiology, Aalborg HospitalAarhus University Hospital
  • Jakob Stegger
    • Department of Cardiology, Aalborg HospitalAarhus University Hospital
  • Anne Tjønneland
    • Institute of Cancer EpidemiologyDanish Cancer Society
  • Marie-Christine Boutron-Ruault
    • INSERM (ERI20) & Paris XI University, Institut Gustave-Roussy
  • Françoise Clavel-Chapelon
    • INSERM (ERI20) & Paris XI University, Institut Gustave-Roussy
  • Sophie Morois
    • INSERM (ERI20) & Paris XI University, Institut Gustave-Roussy
  • Heiner Boeing
    • German Institute of Human Nutrition
  • Rudolf Kaaks
    • Division of Cancer EpidemiologyGerman Cancer Research Center
  • Sabine Rohrmann
    • Division of Cancer EpidemiologyGerman Cancer Research Center
  • Matthäus Vigl
    • German Institute of Human Nutrition
  • Pagona Lagiou
    • Department of Hygiene and EpidemiologyUniversity of Athens Medical School
  • Dimitrios Trichopoulos
    • Department of EpidemiologyHarvard School of Public Health
    • Bureau of Epidemiologic ResearchAcademy of Athens
  • Antonia Trichopoulou
    • Department of Hygiene and EpidemiologyUniversity of Athens Medical School
    • Hellenic Health Foundation
  • H. Bas Bueno-de-Mesquita
    • National Institute for Public Health and the Environment (RIVM)
    • Department of Gastroenterology and HepatologyUniversity Medical Center Utrecht
  • Evelyn M. Monninkhof
    • Julius Center for Health Sciences and Primary CareUniversity Medical Center Utrecht
  • Mattijs E. Numans
    • Julius Center for Health Sciences and Primary CareUniversity Medical Center Utrecht
  • Petra H. Peeters
    • Julius Center for Health Sciences and Primary CareUniversity Medical Center Utrecht
    • Department of Epidemiology and Public HealthImperial College
  • Amalia Mattiello
    • Department of Clinical and Experimental MedicineFederico II University
  • Valeria Pala
    • Department of Preventive and Predictive Medicine, Nutritional Epidemiology UnitFondazione IRCSS Istituto Nazionale dei Tumori
  • Domenico Palli
    • Molecular and Nutritional Epidemiology UnitCSPO-Scientific Institute of Tuscany
  • Rosario Tumino
    • Cancer Registry and Histopathology UnitCivile M.P.Arezzo Hospital
  • Paolo Vineis
    • Department of Epidemiology and Public HealthImperial College
    • ISI Foundation
  • Antonio Agudo
    • Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgrammeCatalan Institute of Oncology
  • Eva Ardanaz
    • CIBER Epidemiología y Salud Pública (CIBERESP)
    • Public Health Institute of Navarra
  • Larraitz Arriola
    • CIBER Epidemiología y Salud Pública (CIBERESP)
    • Public Health Department of GipuzkoaBasque Government
  • Esther Molina-Montes
    • CIBER Epidemiología y Salud Pública (CIBERESP)
    • Andalusian School of Public Health
  • Laudina Rodríguez
    • Public Health Directorate
  • Björn Lindkvist
    • Department of Internal Medicine, Division of Gastroenterology and HepatologySahlgrenska University Hospital
  • Jonas Manjer
    • Department of SurgeryMalmö University Hospital
  • Roger Stenling
    • Department of Medical BiosciencesUniversity of Umeä
  • Eiliv Lund
    • Institute of Community MedicineUniversity of Tromsø
  • Francesca L. Crowe
    • Cancer Epidemiology UnitUniversity of Oxford
  • Timothy J. Key
    • Cancer Epidemiology UnitUniversity of Oxford
  • Kay-Tee Khaw
    • Department of Public Health and Primary Care, Institute of Public Health, School of Clinical MedicineUniversity of Cambridge
  • Nicholas J. Wareham
    • MRC Epidemiology Unit, Institute of Metabolic ScienceUniversity of Cambridge
  • Mazda Jenab
    • Lifestyle, Environment and Cancer GroupInternational Agency for Research on Cancer (IARC)
  • Teresa Norat
    • Department of Epidemiology and Public HealthImperial College
  • Dora Romaguera
    • Department of Epidemiology and Public HealthImperial College
  • Elio Riboli
    • Department of Epidemiology and Public HealthImperial College
  • Carlos A. González
    • Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgrammeCatalan Institute of Oncology
Original paper

DOI: 10.1007/s10552-009-9493-x

Cite this article as:
Huerta, J.M., Navarro, C., Chirlaque, M. et al. Cancer Causes Control (2010) 21: 657. doi:10.1007/s10552-009-9493-x

Abstract

Objective

To analyse the association between types of physical activity (occupational, recreational and household, vigorous and overall) and risk of primary oesophageal (OAC) or gastric adenocarcinoma (GAC).

Methods

From nine European countries, 420,449 participants were recruited between 1991 and 2000 and followed-up for a mean of 8.8 years to register incident GAC and OAC. Information on physical activity (PA), diet, lifestyle and health-related variables was obtained at baseline. Helicobacter pylori infection status was considered in a subset of 1,211 participants. Analyses were repeated by tumour site (cardia/non-cardia) and histological type (intestinal/diffuse).

Results

During the follow-up, 410 GAC and 80 OAC occurred. A lower risk of overall and non-cardia GAC was found for increasing levels of a PA index which combined occupational PA with weekly time spent in sports and cycling. The hazard ratio (HR) of GAC was 0.69, 95% CI: 0.50–0.94, for the comparison between active and inactive participants according to the PA index (HR = 0.44, 95% CI:0.26–0.74, for non-cardia GAC). No effect was found for cardia tumours or histological subtypes of GAC. PA of any kind was not associated with OAC.

Conclusions

Overall and distal (non-cardia) gastric tumours were inversely associated with time spent on cycling and sports and a total PA index. No association was found for any type of PA and risk of cardia cancers of the stomach.

Keywords

Physical activityStomach cancerOesophagus cancerEPIC

Supplementary material

10552_2009_9493_MOESM1_ESM.pdf (34 kb)
Supplementary material 1 (PDF 34 kb)

Copyright information

© Springer Science+Business Media B.V. 2010