Cancer Causes & Control

, Volume 21, Issue 5, pp 657–669

Prospective study of physical activity and risk of primary adenocarcinomas of the oesophagus and stomach in the EPIC (European Prospective Investigation into Cancer and nutrition) cohort

  • José María Huerta
  • Carmen Navarro
  • María-Dolores Chirlaque
  • María-José Tormo
  • Karen Steindorf
  • Genevieve Buckland
  • Fátima Carneiro
  • Nina Føns Johnsen
  • Kim Overvad
  • Jakob Stegger
  • Anne Tjønneland
  • Marie-Christine Boutron-Ruault
  • Françoise Clavel-Chapelon
  • Sophie Morois
  • Heiner Boeing
  • Rudolf Kaaks
  • Sabine Rohrmann
  • Matthäus Vigl
  • Pagona Lagiou
  • Dimitrios Trichopoulos
  • Antonia Trichopoulou
  • H. Bas Bueno-de-Mesquita
  • Evelyn M. Monninkhof
  • Mattijs E. Numans
  • Petra H. Peeters
  • Amalia Mattiello
  • Valeria Pala
  • Domenico Palli
  • Rosario Tumino
  • Paolo Vineis
  • Antonio Agudo
  • Eva Ardanaz
  • Larraitz Arriola
  • Esther Molina-Montes
  • Laudina Rodríguez
  • Björn Lindkvist
  • Jonas Manjer
  • Roger Stenling
  • Eiliv Lund
  • Francesca L. Crowe
  • Timothy J. Key
  • Kay-Tee Khaw
  • Nicholas J. Wareham
  • Mazda Jenab
  • Teresa Norat
  • Dora Romaguera
  • Elio Riboli
  • Carlos A. González
Original paper

DOI: 10.1007/s10552-009-9493-x

Cite this article as:
Huerta, J.M., Navarro, C., Chirlaque, M. et al. Cancer Causes Control (2010) 21: 657. doi:10.1007/s10552-009-9493-x

Abstract

Objective

To analyse the association between types of physical activity (occupational, recreational and household, vigorous and overall) and risk of primary oesophageal (OAC) or gastric adenocarcinoma (GAC).

Methods

From nine European countries, 420,449 participants were recruited between 1991 and 2000 and followed-up for a mean of 8.8 years to register incident GAC and OAC. Information on physical activity (PA), diet, lifestyle and health-related variables was obtained at baseline. Helicobacter pylori infection status was considered in a subset of 1,211 participants. Analyses were repeated by tumour site (cardia/non-cardia) and histological type (intestinal/diffuse).

Results

During the follow-up, 410 GAC and 80 OAC occurred. A lower risk of overall and non-cardia GAC was found for increasing levels of a PA index which combined occupational PA with weekly time spent in sports and cycling. The hazard ratio (HR) of GAC was 0.69, 95% CI: 0.50–0.94, for the comparison between active and inactive participants according to the PA index (HR = 0.44, 95% CI:0.26–0.74, for non-cardia GAC). No effect was found for cardia tumours or histological subtypes of GAC. PA of any kind was not associated with OAC.

Conclusions

Overall and distal (non-cardia) gastric tumours were inversely associated with time spent on cycling and sports and a total PA index. No association was found for any type of PA and risk of cardia cancers of the stomach.

Keywords

Physical activityStomach cancerOesophagus cancerEPIC

Supplementary material

10552_2009_9493_MOESM1_ESM.pdf (34 kb)
Supplementary material 1 (PDF 34 kb)

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • José María Huerta
    • 1
    • 2
    • 37
  • Carmen Navarro
    • 1
    • 2
  • María-Dolores Chirlaque
    • 1
    • 2
  • María-José Tormo
    • 1
    • 2
  • Karen Steindorf
    • 3
  • Genevieve Buckland
    • 4
  • Fátima Carneiro
    • 5
  • Nina Føns Johnsen
    • 6
  • Kim Overvad
    • 7
    • 8
  • Jakob Stegger
    • 7
  • Anne Tjønneland
    • 6
  • Marie-Christine Boutron-Ruault
    • 9
  • Françoise Clavel-Chapelon
    • 9
  • Sophie Morois
    • 9
  • Heiner Boeing
    • 10
  • Rudolf Kaaks
    • 11
  • Sabine Rohrmann
    • 11
  • Matthäus Vigl
    • 10
  • Pagona Lagiou
    • 12
  • Dimitrios Trichopoulos
    • 13
    • 14
  • Antonia Trichopoulou
    • 12
    • 15
  • H. Bas Bueno-de-Mesquita
    • 16
    • 17
  • Evelyn M. Monninkhof
    • 18
  • Mattijs E. Numans
    • 18
  • Petra H. Peeters
    • 18
    • 19
  • Amalia Mattiello
    • 20
  • Valeria Pala
    • 21
  • Domenico Palli
    • 22
  • Rosario Tumino
    • 23
  • Paolo Vineis
    • 19
    • 24
  • Antonio Agudo
    • 4
  • Eva Ardanaz
    • 1
    • 25
  • Larraitz Arriola
    • 1
    • 26
  • Esther Molina-Montes
    • 1
    • 27
  • Laudina Rodríguez
    • 28
  • Björn Lindkvist
    • 29
  • Jonas Manjer
    • 30
  • Roger Stenling
    • 31
  • Eiliv Lund
    • 32
  • Francesca L. Crowe
    • 33
  • Timothy J. Key
    • 33
  • Kay-Tee Khaw
    • 34
  • Nicholas J. Wareham
    • 35
  • Mazda Jenab
    • 36
  • Teresa Norat
    • 19
  • Dora Romaguera
    • 19
  • Elio Riboli
    • 19
  • Carlos A. González
    • 4
  1. 1.CIBER Epidemiología y Salud Pública (CIBERESP)BarcelonaSpain
  2. 2.Epidemiology DepartmentRegional Council of Health and Consumer AffairsMurciaSpain
  3. 3.Unit of Environmental EpidemiologyGerman Cancer Research CenterHeidelbergGermany
  4. 4.Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgrammeCatalan Institute of OncologyBarcelona (ICO-IDIBELL)Spain
  5. 5.Institute of Molecular Pathology and Immunology of the University of Porto and Medical FacultyPortoPortugal
  6. 6.Institute of Cancer EpidemiologyDanish Cancer SocietyCopenhagenDenmark
  7. 7.Department of Cardiology, Aalborg HospitalAarhus University HospitalAalborgDenmark
  8. 8.Department of Clinical Epidemiology, Aalborg HospitalAarhus University HospitalAalborgDenmark
  9. 9.INSERM (ERI20) & Paris XI University, Institut Gustave-RoussyVillejuifFrance
  10. 10.German Institute of Human NutritionPotsdam-RehbückeGermany
  11. 11.Division of Cancer EpidemiologyGerman Cancer Research CenterHeidelbergGermany
  12. 12.Department of Hygiene and EpidemiologyUniversity of Athens Medical SchoolAthensGreece
  13. 13.Department of EpidemiologyHarvard School of Public HealthBostonUSA
  14. 14.Bureau of Epidemiologic ResearchAcademy of AthensAthensGreece
  15. 15.Hellenic Health FoundationAthensGreece
  16. 16.National Institute for Public Health and the Environment (RIVM)BilthovenThe Netherlands
  17. 17.Department of Gastroenterology and HepatologyUniversity Medical Center UtrechtUtrechtThe Netherlands
  18. 18.Julius Center for Health Sciences and Primary CareUniversity Medical Center UtrechtUtrechtThe Netherlands
  19. 19.Department of Epidemiology and Public HealthImperial CollegeLondonUK
  20. 20.Department of Clinical and Experimental MedicineFederico II UniversityNaplesItaly
  21. 21.Department of Preventive and Predictive Medicine, Nutritional Epidemiology UnitFondazione IRCSS Istituto Nazionale dei TumoriMilanItaly
  22. 22.Molecular and Nutritional Epidemiology UnitCSPO-Scientific Institute of TuscanyFlorenceItaly
  23. 23.Cancer Registry and Histopathology UnitCivile M.P.Arezzo HospitalRagusaItaly
  24. 24.ISI FoundationTorinoItaly
  25. 25.Public Health Institute of NavarraPamplonaSpain
  26. 26.Public Health Department of GipuzkoaBasque GovernmentSan SebastianSpain
  27. 27.Andalusian School of Public HealthGranadaSpain
  28. 28.Public Health DirectorateAsturiasSpain
  29. 29.Department of Internal Medicine, Division of Gastroenterology and HepatologySahlgrenska University HospitalGothenburgSweden
  30. 30.Department of SurgeryMalmö University HospitalMalmöSweden
  31. 31.Department of Medical BiosciencesUniversity of UmeäUmeäSweden
  32. 32.Institute of Community MedicineUniversity of TromsøTromsøNorway
  33. 33.Cancer Epidemiology UnitUniversity of OxfordOxfordUK
  34. 34.Department of Public Health and Primary Care, Institute of Public Health, School of Clinical MedicineUniversity of CambridgeCambridgeUK
  35. 35.MRC Epidemiology Unit, Institute of Metabolic ScienceUniversity of CambridgeCambridgeUK
  36. 36.Lifestyle, Environment and Cancer GroupInternational Agency for Research on Cancer (IARC)LyonFrance
  37. 37.Servicio de Epidemiología, Consejería Sanidad y ConsumoMurciaSpain