Original paper

Cancer Causes & Control

, Volume 21, Issue 2, pp 269-274

First online:

Increasing trend of the incidence of esophageal squamous cell carcinoma, but not adenocarcinoma, in Taiwan

  • Ching-Liang LuAffiliated withDivision of Gastroenterology, Taipei Veterans General HospitalInstitute of Brain Science, National Yang-Ming UniversitySchool of Medicine, National Yang-Ming University Email author 
  • , Hui-Chu LangAffiliated withInstitute of Hospital and Health Care Administration, National Yang-Ming University
  • , Jiing-Chyuan LuoAffiliated withDivision of Gastroenterology, Taipei Veterans General HospitalSchool of Medicine, National Yang-Ming University
  • , Chun-Chu LiuAffiliated withDepartment of Medicine, Koo Foundation Sun Yat-Sen Cancer CenterSchool of Medicine, National Yang-Ming University
  • , Han-Chieh LinAffiliated withDivision of Gastroenterology, Taipei Veterans General HospitalSchool of Medicine, National Yang-Ming University
  • , Full-Young ChangAffiliated withDivision of Gastroenterology, Taipei Veterans General HospitalSchool of Medicine, National Yang-Ming University
  • , Shou-Dong LeeAffiliated withDivision of Gastroenterology, Taipei Veterans General HospitalSchool of Medicine, National Yang-Ming University

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Abstract

Epidemiologic data on esophageal cancer in Asia are extremely limited. We examined temporal trends in the incidence of esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EA) in Taiwan. Patients with esophageal cancer were identified from the Taiwan Cancer Registry between 1979 and 2003. Age-standardized incidences of ESCC and EA were calculated based on the national census and world standard population. Trends in incidence rates were estimated by calculating the annual percentage change (APC). The age-standardized incidence of ESCC increased progressively (from 1979–1983 to 1999–2003: 2.63 to 4.37 per 100,000-year), with an APC higher in male (3.27%, P < 0.0001) than that in female (1.23%, P = 0.03). Though the crude incidence of EA progressively increased in both gender (male: 0.28–0.49 per 100,000-year; female 0.07–0.11 per 100,000-year), the age-standardized incidence of EA is similar along the study period with an APC of 0.72% (P = 0.20) in male and 1.59% (P = 0.30) in female. In Taiwan, the incidence of ESCC significantly increased from 1979 to 2003, whereas the incidence of EA remained unchanged. Although EA incidence has not recently increased, it could in the future.

Keywords

Esophagus cancer Squamous cell carcinoma Adenocarcinoma Taiwan