, Volume 21, Issue 2, pp 181-189
Date: 15 Oct 2009

Family history of cancer and malignant germ cell tumors in children: A report from the Children’s Oncology Group

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Abstract

Family history of testicular cancer is an established risk factor for adult testicular germ cell tumors (GCT). We evaluated the association between family history of cancer and pediatric GCT in a Children’s Oncology Group case–control study that included 274 GCT cases (195 female and 79 male) diagnosed Odds Ratio (OR) = 0.50, 95% Confidence Interval (CI) 0.28–0.89) and an increased risk among male cases (OR = 2.56, 95% CI 1.02–6.44). Male cases were more likely to report family history of melanoma compared with male controls (OR = 4.65, 95% CI 1.40–15.4). There was an inverse association between family history of ovarian or uterine cancers and GCT in girls (OR = 0.46, 95% CI 0.22–0.96). These sex and cancer site specific associations should be confirmed in additional studies as they may provide clues to the etiology of pediatric GCT.