Cancer Causes & Control

, Volume 21, Issue 1, pp 163–170

Atrophic gastritis and the risk of incident colorectal cancer

Authors

    • Cancer Prevention Fellowship Program, Office of Preventive OncologyNational Cancer Institute (NCI), National Institutes of Health (NIH)
    • Biometry Research Group, Division of Cancer PreventionNational Cancer Institute (NCI), National Institutes of Health (NIH)
    • Cancer Prevention Fellowship Program, Biometry Research Group, Division of Cancer PreventionNational Cancer Institute
  • Farin Kamangar
    • Nutritional Epidemiology Branch, Division of Cancer Epidemiology and GeneticsNational Cancer Institute (NCI), National Institutes of Health (NIH)
    • Department of Public Health Analysis, School of Community Health and PolicyMorgan State University
  • Pamela M. Marcus
    • Biometry Research Group, Division of Cancer PreventionNational Cancer Institute (NCI), National Institutes of Health (NIH)
  • Philip R. Taylor
    • Genetic Epidemiology Branch, Division of Cancer Epidemiology and GeneticsNational Cancer Institute (NCI), National Institutes of Health (NIH)
  • Jarmo Virtamo
    • Department of Chronic Disease PreventionNational Institute for Health and Welfare
  • Demetrius Albanes
    • Nutritional Epidemiology Branch, Division of Cancer Epidemiology and GeneticsNational Cancer Institute (NCI), National Institutes of Health (NIH)
  • Rachael Z. Stolzenberg-Solomon
    • Nutritional Epidemiology Branch, Division of Cancer Epidemiology and GeneticsNational Cancer Institute (NCI), National Institutes of Health (NIH)
Original paper

DOI: 10.1007/s10552-009-9446-4

Cite this article as:
Laiyemo, A.O., Kamangar, F., Marcus, P.M. et al. Cancer Causes Control (2010) 21: 163. doi:10.1007/s10552-009-9446-4

Abstract

Previous studies evaluating whether risk factors for gastric cancer are also associated with colorectal cancer (CRC) have shown inconsistent results. We prospectively examined the association of atrophic gastritis, a pre-malignant condition for gastric cancer and long-term sequelae common to many exposure factors, and the risk of incident CRC.

Methods

A total of 20,928 Finnish male smokers, aged 50–69, who were participants in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC) had serum pepsinogen I (SPGI) levels measured. Participants with low SPGI levels (<25 μg/l; n = 1,665) were invited for gastroscopy. Of these, 1,059 (63.6%) participants underwent gastroscopy and atrophic gastritis was histologically confirmed in 1,006 (95.0%) participants. We used Cox proportional hazards regression to evaluate the risk of incident CRC.

Results

During a mean follow-up of 11.3 years (236,258 person-years), 425 incident CRCs were diagnosed. The incidence rates were 1.82, 1.48, and 1.82 per 1,000 person-years of follow-up for participants with normal SPGI (≥25 μg/l), low SPGI, and histologically confirmed atrophic gastritis, respectively. Compared to subjects with normal SPGI, there was no increased risk of CRC among subjects with low SPGI (Adjusted Hazard Ratio (HR) = 0.71; 95% CI: 0.47–1.05) and among those with histologically confirmed atrophic gastritis (Adjusted HR = 0.86; 95% CI: 0.55–1.34).

Conclusion

Atrophic gastritis is not associated with an increased risk of colorectal cancer among male smokers.

Keywords

Serum pepsinogenAtrophic gastritisColorectal cancer

Abbreviations

ATBC

Alpha-tocopherol, beta-carotene cancer prevention study

CI

Confidence interval

CRC

Colorectal cancer

HR

Hazard ratio

SPGI

Serum pepsinogen I

Copyright information

© US Government  2009