Cancer Causes & Control

, Volume 21, Issue 1, pp 1–10

Metabolic syndrome components and colorectal adenoma in the CLUE II cohort

  • Konstantinos K. Tsilidis
  • Frederick L. Brancati
  • Michael N. Pollak
  • Nader Rifai
  • Sandra L. Clipp
  • Judith Hoffman-Bolton
  • Kathy J. Helzlsouer
  • Elizabeth A. Platz
Original Paper

DOI: 10.1007/s10552-009-9428-6

Cite this article as:
Tsilidis, K.K., Brancati, F.L., Pollak, M.N. et al. Cancer Causes Control (2010) 21: 1. doi:10.1007/s10552-009-9428-6

Abstract

Background

Metabolic syndrome components have been associated with colorectal cancer in several studies; however, evidence for colorectal adenomas is limited. Thus, we evaluated the association between markers of the metabolic syndrome with colorectal adenoma development in a nested case–control study.

Methods

Colorectal adenoma cases (n = 132) and matched controls, who had a negative sigmoidoscopy or a colonoscopy (n = 260), were identified between baseline in 1989 and 2000 among participants in the CLUE II cohort of Washington County, Maryland. Concentrations of C-peptide, insulin-like growth factor binding protein-1, glycosylated hemoglobin, total cholesterol, high-density lipoprotein cholesterol, and triglycerides were measured in baseline blood specimens. Body mass index was calculated using baseline height and weight. Use of medications to treat diabetes mellitus was self-reported at baseline. Blood pressure was measured at baseline. Distributional cutpoints of the latter markers were used to define the metabolic syndrome components (hyperinsulinemia, hyperglycemia, obesity, dyslipidemia, and hypertension) present at baseline.

Results

No statistically significant associations with adenomas were observed for the markers of the metabolic syndrome, with the exception of a strong positive association for use of diabetes medications (OR, 8.00; 95% CI, 1.70–37.67), albeit based on small numbers.

Conclusion

Our findings do not support that components of the metabolic syndrome influence risk of colorectal adenomas, except possibly for severe diabetes mellitus warranting medical treatment.

Keywords

Insulin resistance Colorectal neoplasia Prospective study 

Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Konstantinos K. Tsilidis
    • 1
  • Frederick L. Brancati
    • 1
    • 2
    • 3
  • Michael N. Pollak
    • 4
  • Nader Rifai
    • 5
  • Sandra L. Clipp
    • 1
    • 6
  • Judith Hoffman-Bolton
    • 6
  • Kathy J. Helzlsouer
    • 1
    • 6
    • 7
    • 8
  • Elizabeth A. Platz
    • 1
    • 8
  1. 1.Department of EpidemiologyJohns Hopkins Bloomberg School of Public HealthBaltimoreUSA
  2. 2.Division of General Internal Medicine, Department of MedicineJohns Hopkins School of MedicineBaltimoreUSA
  3. 3.Welch Center for Prevention, Epidemiology, and Clinical ResearchJohns Hopkins UniversityBaltimoreUSA
  4. 4.Departments of Medicine and OncologyJewish General Hospital and McGill UniversityMontrealCanada
  5. 5.Department of Laboratory MedicineChildren’s Hospital and Harvard Medical SchoolBostonUSA
  6. 6.George W. Comstock Center for Public Health Research and PreventionJohns Hopkins Bloomberg School of Public HealthHagerstownUSA
  7. 7.Prevention and Research CenterWeinberg Center for Women’s Health and Medicine, Mercy Medical CenterBaltimoreUSA
  8. 8.The Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins Medical InstitutionsBaltimoreUSA

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