Cancer Causes & Control

, 20:1623

Correlates of sexually transmitted infection histories in a cohort of American male health professionals

  • Siobhan Sutcliffe
  • Ichiro Kawachi
  • John F. Alderete
  • Charlotte A. Gaydos
  • Lisa P. Jacobson
  • Frank J. Jenkins
  • Raphael P. Viscidi
  • Jonathan M. Zenilman
  • Elizabeth A. Platz
Original paper

DOI: 10.1007/s10552-009-9409-9

Cite this article as:
Sutcliffe, S., Kawachi, I., Alderete, J.F. et al. Cancer Causes Control (2009) 20: 1623. doi:10.1007/s10552-009-9409-9

Abstract

Objective

Several epidemiologic studies have investigated sexually transmitted infections (STIs) and later risk of genitourinary conditions with suggestive positive results. While these results may reflect causal associations, other possible explanations include confounding by factors possibly related to both STI acquisition and genitourinary condition risk such as recognized STI-risk factors/correlates, and other factors not typically considered in relation to STIs (e.g., general health-related behaviors or markers of such behaviors). Very few of these factors have been investigated in older populations in which STIs and genitourinary conditions are typically studied. Therefore, we investigated STI history correlates in one such population, the Health Professionals Follow-up Study.

Methods

We ascertained histories of potential correlates, gonorrhea, syphilis by questionnaire (n = 36,032), and performed serologic testing for Chlamydia trachomatis, Trichomonas vaginalis, human papillomavirus, and human herpesvirus type 8 infection in a subset (n = 651).

Results

Positive correlations were observed for African–American race, foreign birth, southern residence, smoking, alcohol consumption, ejaculation frequency, vasectomy, and high cholesterol. Inverse correlations were observed for social integration and routine health-related examinations.

Conclusions

These findings provide useful information on potential confounders for epidemiologic investigations of STIs and chronic diseases, and interesting new hypotheses for STI prevention (e.g., STI counseling before vasectomy).

Keywords

Sexually transmitted diseasesEpidemiologyConfounding factor (epidemiology)

Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Siobhan Sutcliffe
    • 1
  • Ichiro Kawachi
    • 2
  • John F. Alderete
    • 3
  • Charlotte A. Gaydos
    • 4
  • Lisa P. Jacobson
    • 5
  • Frank J. Jenkins
    • 6
    • 9
  • Raphael P. Viscidi
    • 7
  • Jonathan M. Zenilman
    • 4
  • Elizabeth A. Platz
    • 5
    • 8
  1. 1.Alvin J. Siteman Cancer Center and the Department of SurgeryWashington University School of MedicineSt. LouisUSA
  2. 2.Department of Society, Human Development and HealthHarvard School of Public HealthBostonUSA
  3. 3.School of Molecular Biosciences, Fulmer HallWashington State UniversityPullmanUSA
  4. 4.Division of Infectious Diseases, Department of MedicineJohns Hopkins Medical InstitutionsBaltimoreUSA
  5. 5.Department of EpidemiologyJohns Hopkins Bloomberg School of Public HealthBaltimoreUSA
  6. 6.Department of Pathology, School of MedicineUniversity of PittsburghPittsburghUSA
  7. 7.Stanley Division of Developmental Neurovirology, Department of PediatricsJohns Hopkins Medical InstitutionsBaltimoreUSA
  8. 8.James Buchanan Brady Urological Institute, Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins Medical InstitutionsBaltimoreUSA
  9. 9.Departments of Infectious Diseases and Microbiology, School of Public HealthUniversity of PittsburghPittsburghUSA