, Volume 20, Issue 8, pp 1451-1458
Date: 17 Jun 2009

Dietary vitamin C, E, and carotenoid intake and risk of renal cell carcinoma

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The study examines the association between dietary intake of vitamin C, E, and carotenoids and the risk of renal cell carcinoma (RCC).


Between 1994 and 1997 in 8 Canadian provinces, mailed questionnaires were completed by 1,138 incident, histologically confirmed cases of RCC and 5,039 population controls, including information on socio-economic status, lifestyle habits and diet. A 69-item food frequency questionnaire provided data on eating habits 2 years before data collection. Odds ratios (OR) and 95% confidence intervals (CI) were computed using unconditional logistic regression.


Dietary intake of β-carotene and lutein/zeaxanthin was inversely associated with the risk of RCC. The ORs for the highest versus the lowest quartile were 0.74 (95% CI, 0.59–0.92) and 0.77 (95% CI, 0.62–0.95), respectively. The significant inverse association with β-carotene and lutein/zeaxanthin was more pronounced in women, and in overweight or obese subjects. The relation of lutein/zeaxanthin to RCC was stronger in ever smokers. No clear association was observed with vitamin C and E, β-cryptozanthin, and lycopene.


The findings provide evidence that a diet rich in β-carotene and lutein/zeaxanthin may play a role in RCC prevention.

The Canadian Cancer Registries Epidemiology Research Group comprises a principal investigator from each of the provincial cancer registries involved in the National Enhanced Cancer Surveillance System: Bertha Paulse, MSc, BN, Newfoundland Cancer Foundation; Ron Dewar, MA, Nova Scotia Cancer Registry; Dagny Dryer, MD, Prince Edward Island Cancer Registry; Nancy Kreiger, PhD, Cancer Care Ontario; Heather Whittaker, Manitoba Cancer Treatment and Research Foundation; Diane Robson, BA, Saskatchewan Cancer Foundation; Shirley Fincham, PhD, Alberta Cancer Board; and Nhu Le, PhD, British Columbia Cancer Agency.