Cancer Causes & Control

, Volume 20, Issue 8, pp 1451–1458

Dietary vitamin C, E, and carotenoid intake and risk of renal cell carcinoma

Authors

    • Evidence and Risk Assessment Division, Centre for Chronic Disease Prevention and ControlPublic Health Agency of Canada
  • Carlo La  Vecchia
    • Istituto Di Ricerche Farmacologiche “Mario Negri”
    • Istituto di Statistica Medica e BiometriaUniversità degli Studi di Milano
  • Eva Negri
    • Istituto Di Ricerche Farmacologiche “Mario Negri”
  • Marie DesMeules
    • Evidence and Risk Assessment Division, Centre for Chronic Disease Prevention and ControlPublic Health Agency of Canada
  • Les Mery
    • Canadian Partnership Against Cancer
  • The Canadian Cancer Registries Epidemiology Research Group
Original paper

DOI: 10.1007/s10552-009-9371-6

Cite this article as:
Hu, J., La Vecchia, C., Negri, E. et al. Cancer Causes Control (2009) 20: 1451. doi:10.1007/s10552-009-9371-6

Abstract

Object

The study examines the association between dietary intake of vitamin C, E, and carotenoids and the risk of renal cell carcinoma (RCC).

Methods

Between 1994 and 1997 in 8 Canadian provinces, mailed questionnaires were completed by 1,138 incident, histologically confirmed cases of RCC and 5,039 population controls, including information on socio-economic status, lifestyle habits and diet. A 69-item food frequency questionnaire provided data on eating habits 2 years before data collection. Odds ratios (OR) and 95% confidence intervals (CI) were computed using unconditional logistic regression.

Results

Dietary intake of β-carotene and lutein/zeaxanthin was inversely associated with the risk of RCC. The ORs for the highest versus the lowest quartile were 0.74 (95% CI, 0.59–0.92) and 0.77 (95% CI, 0.62–0.95), respectively. The significant inverse association with β-carotene and lutein/zeaxanthin was more pronounced in women, and in overweight or obese subjects. The relation of lutein/zeaxanthin to RCC was stronger in ever smokers. No clear association was observed with vitamin C and E, β-cryptozanthin, and lycopene.

Conclusion

The findings provide evidence that a diet rich in β-carotene and lutein/zeaxanthin may play a role in RCC prevention.

Keywords

Kidney cancerRiskCarotenoidsCanada

Abbreviations

BMI

Body mass index

OR

Odds ratio

CI

Confidence interval

NECSS

National Enhanced Cancer Surveillance System

RCC

Renal cell carcinoma

FFQ

Food frequency questionnaire

Copyright information

© Springer Science+Business Media B.V. 2009