Viral and non-viral risk factors for non-Hodgkin’s lymphoma in Egypt: heterogeneity by histological and immunological subtypes
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Non-Hodgkin’s lymphomas (NHL) are etiologically heterogeneous malignancies. In Egypt, we previously reported an association of increased NHL risk with chronic hepatitis C virus (HCV) infection. Our present aim is to assess the association between HCV infection and histological subtypes of NHL.
We conducted a case–control study at the National Cancer Institute of Cairo University. Cases with NHL (n = 486) were matched to controls (n = 786) who were orthopedic patients from the same referral regions. Participants provided a blood sample for HCV markers (anti-HCV, HCV RNA) and answered a questionnaire on possible risk factors. Case–control differences were assessed by odds ratios and 95% confidence intervals from logistic regression analysis.
Cases with diffuse large B cell lymphoma (n = 146), chronic lymphocytic leukemia (n = 58), marginal zone lymphoma (n = 24), follicular lymphoma (n = 23), and mantle cell lymphoma (n = 16) were recruited. HCV RNA prevalence was 27% in controls and 26%–48% in the NHL subgroups: it was associated (p < 0.001) with diffuse large B cell, marginal zone, and follicular lymphomas with odds ratios of 3.2, 4.4, and 3.3, respectively.
HCV is a risk factor for diffuse large B cell, marginal zone, and follicular lymphomas in Egypt.
- Viral and non-viral risk factors for non-Hodgkin’s lymphoma in Egypt: heterogeneity by histological and immunological subtypes
Cancer Causes & Control
Volume 20, Issue 6 , pp 981-987
- Cover Date
- Print ISSN
- Online ISSN
- Springer Netherlands
- Additional Links
- Non-Hodgkin’s lymphoma
- Hepatitis C virus
- Risk factors
- Industry Sectors
- Author Affiliations
- 1. Lombardi Cancer Center, Georgetown University, 3800 Reservoir Rd, P.O. Box 571465, Washington, DC, 20057-1465, USA
- 3. National Liver Institute, Shibin El Kom, Egypt
- 4. National Cancer Institute, Cairo University, Cairo, Egypt
- 2. MD Anderson, Houston, TX, USA
- 5. Minia University, Minia, Egypt