Association of serum phospholipid fatty acids with breast cancer risk among postmenopausal cigarette smokers
- Yumie TakataAffiliated withFred Hutchinson Cancer Research Center
- , Irena B. KingAffiliated withFred Hutchinson Cancer Research Center
- , Marian L. NeuhouserAffiliated withFred Hutchinson Cancer Research Center
- , Steve SchafferAffiliated withHarrison Medical Center
- , Matt BarnettAffiliated withFred Hutchinson Cancer Research Center
- , Mark ThornquistAffiliated withFred Hutchinson Cancer Research Center
- , Ulrike PetersAffiliated withFred Hutchinson Cancer Research Center Email author
- , Gary E. GoodmanAffiliated withFred Hutchinson Cancer Research CenterSwedish Medical Center Tumor Institute
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To examine the association between breast cancer risk and the fatty acid composition of phospholipids in prediagnostic serum samples.
We analyzed the fatty acid composition in 130 incident postmenopausal breast cancer cases and 257 matched controls nested within the β-Carotene and Retinol Efficacy Trial Cohort. The fatty acid composition was measured by gas chromatography. Multivariate-adjusted odds ratios and corresponding 95% confidence intervals for the risk of breast cancer were estimated using logistic regression. Stratified analysis was conducted by smoking status.
There were no associations with breast cancer risk for total saturated, monounsaturated, n-3, n-6, or trans fatty acids among all women. For individual fatty acids, we observed an inverse association with the trans linoleic acid, 18:2n6tt (p trend = 0.0002). Among current smokers, long-chain saturated fatty acids (22:0 and 24:0) and total 16:1 trans fatty acids were positively associated with the risk of breast cancer, whereas these fatty acids showed no association among former smokers.
Overall, we observed no significant association between serum phospholipid fatty acids and breast cancer risk, except for the trans linoleic acid isomer 18:2n6tt, which was unexpected. Our finding of a positive association of long-chain saturated fatty acids (22:0 and 24:0) and total 16:1 trans fatty acids with the risk of breast cancer only in current smokers may suggest an effect modification by smoking status. Our findings need to be replicated in future epidemiologic studies.
KeywordsFatty acid Breast cancer Postmenopausal women Smoking
- Association of serum phospholipid fatty acids with breast cancer risk among postmenopausal cigarette smokers
Cancer Causes & Control
Volume 20, Issue 4 , pp 497-504
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- Springer Netherlands
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- Fatty acid
- Breast cancer
- Postmenopausal women
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- Author Affiliations
- 1. Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North M4-B402, Seattle, WA, 98109-1024, USA
- 2. Harrison Medical Center, 2520 Cherry Avenue, Bremerton, WA, 98310, USA
- 3. Swedish Medical Center Tumor Institute, 747 Broadway, Seattle, WA, 98122, USA