Cancer Causes & Control

, Volume 20, Issue 7, pp 1055–1060

Serum total cholesterol and the risk of breast cancer in postmenopausal Korean women

Original Paper

DOI: 10.1007/s10552-009-9301-7

Cite this article as:
Ha, M., Sung, J. & Song, YM. Cancer Causes Control (2009) 20: 1055. doi:10.1007/s10552-009-9301-7

Abstract

Objective

To evaluate an association between serum total cholesterol level and breast cancer risk, for which inconsistent findings have been reported in spite of the role of serum cholesterol as a precursor to a breast cancer-related sex steroid hormone.

Methods

Postmenopausal Korean women (= 170,374), categorized into four groups by quartiles of cholesterol level, were followed up for occurrence of breast cancer from 1993 to 2003. Relative risks were assessed by Cox proportional hazard analysis.

Results

A positive association between cholesterol level and breast cancer risk was found with 31% greater age-adjusted risk of breast cancer in the highest cholesterol group (≥5.95 mmol/l) than that in the lowest cholesterol group (<4.63 mmol/l). The strength of association was reduced slightly but persisted after the adjustment for reproductive and behavioral covariates. However, the association further attenuated and the positive trend was no longer significant when BMI was additionally adjusted (p-trend, 0.0684). Stratified analysis by BMI showed that the risk of breast cancer increased with increasing cholesterol level only in normal BMI (<25 kg/m2) group, but the interaction term was not significant.

Conclusion

Serum total cholesterol level is not associated with the risk of breast cancer in postmenopausal Korean women.

Keywords

Body mass indexBreast neoplasmsCholesterolKoreansPostmenopause

Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  1. 1.Department of Preventive MedicineDankook University College of MedicineCheonanSouth Korea
  2. 2.Department of Epidemiology, The Graduate School of Public Health and Institute of Health and EnvironmentSeoul National UniversitySeoulSouth Korea
  3. 3.Department of Epidemiology and Cancer PreventionNational Cancer CenterGoyangSouth Korea
  4. 4.Department of Family Medicine, Samsung Medical Center, and Center for Clinical Research, Samsung Biomedical Research InstituteSungKyunKwan University School of MedicineSeoulSouth Korea