Cancer Causes & Control

, Volume 20, Issue 5, pp 785–794

Ethanol intake and the risk of pancreatic cancer in the European prospective investigation into cancer and nutrition (EPIC)

Authors

    • Division of Clinical EpidemiologyGerman Cancer Research Centre
  • Jakob Linseisen
    • Division of Clinical EpidemiologyGerman Cancer Research Centre
  • Alina Vrieling
    • National Institute of Public Health and the Environment (RIVM)
    • Julius CenterUniversity Medical Center Utrecht
  • Paolo Boffetta
    • International Agency for Research on Cancer (IARC–WHO)
  • Rachael Z. Stolzenberg-Solomon
    • Nutritional Epidemiology Branch, Division of Cancer Epidemiology and GeneticsNational Cancer Institute, National Institutes of Health, Department of Health and Human Services
  • Albert B. Lowenfels
    • New York Medical College
  • Majken K. Jensen
    • Department of Clinical Epidemiology, Aalborg HospitalAarhus University Hospital
  • Kim Overvad
    • Department of Clinical Epidemiology, Aalborg HospitalAarhus University Hospital
  • Anja Olsen
    • Institute of Cancer EpidemiologyDanish Cancer Society
  • Anne Tjonneland
    • Institute of Cancer EpidemiologyDanish Cancer Society
  • Marie-Christine Boutron-Ruault
    • Inserm ERI20, Paris XI University, Institut Gustave-Roussy
  • Francoise Clavel-Chapelon
    • Inserm ERI20, Paris XI University, Institut Gustave-Roussy
  • G. Fagherazzi
    • Inserm ERI20, Paris XI University, Institut Gustave-Roussy
  • Gesthimani Misirli
    • Department of Hygiene and EpidemiologyUniversity of Athens Medical School
  • Pagona Lagiou
    • Department of Hygiene and EpidemiologyUniversity of Athens Medical School
  • Antonia Trichopoulou
    • Department of Hygiene and EpidemiologyUniversity of Athens Medical School
  • Rudolf Kaaks
    • Division of Clinical EpidemiologyGerman Cancer Research Centre
  • Manuela M. Bergmann
    • Department of EpidemiologyGerman Institute of Human Nutrition
  • Heiner Boeing
    • Department of EpidemiologyGerman Institute of Human Nutrition
  • Sheila Bingham
    • MRC Dunn Human Nutrition Unit
  • Kay-Tee Khaw
    • Department of Public Health and Primary Care, Institute of Public HealthUniversity of Cambridge School of Clinical Medicine
  • Naomi Allen
    • Cancer Epidemiology UnitUniversity of Oxford
  • Andrew Roddam
    • Cancer Epidemiology UnitUniversity of Oxford
  • Domenico Palli
    • Molecular and Nutritional Epidemiology UnitCancer Research and Prevention Institute (ISPO)
  • Valeria Pala
    • Nutritional Epidemiology UnitNational Cancer Institute
  • Salvatore Panico
    • Department of Clinical and Experimental MedicineFederico II University
  • Rosario Tumino
    • Cancer Registry, Azienda Ospedaliera “Civile MP Arezzo”
  • Paolo Vineis
    • Environmental EpidemiologyImperial College London
  • Petra H. M. Peeters
    • Julius CenterUniversity Medical Center Utrecht
    • Faculty of Medicine, Department of Epidemiology and Public HealthImperial College London
  • Anette Hjartåker
    • Cancer Registry of NorwayInsititute of Population-Based Cancer Research
  • Eiliv Lund
    • Institute of Community MedicineUniversity of Tromsø
  • Ma Luisa Redondo Cornejo
    • Health and Health Services Council of Asturias, Public Health Directorate
  • Antonio Agudo
    • Unit of Nutrition, Environment and CancerCatalan Institute of Oncology
  • Larraitz Arriola
    • Public Health Department of Gipuzkoa, Basque Government
    • Ciber en Epidemiologia y Salud Pública (CIBERESP)
  • Maria-José Sánchez
    • Ciber en Epidemiologia y Salud Pública (CIBERESP)
    • Andalusian School of Public Health
  • María-José Tormo
    • Ciber en Epidemiologia y Salud Pública (CIBERESP)
    • Department of EpidemiologyMurcia Regional Health Council
  • Aurelio Barricarte Gurrea
    • Ciber en Epidemiologia y Salud Pública (CIBERESP)
    • Public Health Institute of Navarra
  • Björn Lindkvist
    • Division of Gastroenterology and Hepatology, Department of Internal MedicineSahlgrenska University Hospital
  • Jonas Manjer
    • Department of SurgeryMalmö University Hospital
  • Ingegerd Johansson
    • Department of Odontology, CardiologyUmeå University Hospital
  • Weimin Ye
    • Department of Medical Epidemiology and BiostatisticsKarolinska Institute
  • Nadia Slimani
    • International Agency for Research on Cancer (IARC–WHO)
  • Eric J. Duell
    • International Agency for Research on Cancer (IARC–WHO)
  • Mazda Jenab
    • International Agency for Research on Cancer (IARC–WHO)
  • Dominique S. Michaud
    • Faculty of Medicine, Department of Epidemiology and Public HealthImperial College London
  • Traci Mouw
    • Faculty of Medicine, Department of Epidemiology and Public HealthImperial College London
  • Elio Riboli
    • Faculty of Medicine, Department of Epidemiology and Public HealthImperial College London
  • H. Bas Bueno-de-Mesquita
    • National Institute of Public Health and the Environment (RIVM)
Original Paper

DOI: 10.1007/s10552-008-9293-8

Cite this article as:
Rohrmann, S., Linseisen, J., Vrieling, A. et al. Cancer Causes Control (2009) 20: 785. doi:10.1007/s10552-008-9293-8

Abstract

Objective

To examine the association of baseline and lifetime ethanol intake with cancer of the pancreas in the European Prospective Investigation into Cancer and Nutrition (EPIC).

Methods

Included in this analysis were 478,400 subjects, of whom detailed information on the intake of alcoholic beverages at baseline and over lifetime was collected between 1992 and 2000. During a median follow-up time of 8.9 years, 555 non-endocrine pancreatic cancer cases were observed. Multivariate Cox proportional hazard models were used to examine the association of ethanol intake at recruitment and average lifetime ethanol intake and pancreatic cancer adjusting for smoking, height, weight, and history of diabetes.

Results

Overall, neither ethanol intake at recruitment (relative risk (RR) = 0.94, 95% confidence interval (CI) 0.69–1.27 comparing 30+ g/d vs. 0.1–4.9 g/d) nor average lifetime ethanol intake (RR = 0.95, 95% CI 0.65–1.39) was associated with pancreatic cancer risk. High lifetime ethanol intake from spirits/liquor at recruitment tended to be associated with a higher risk (RR = 1.40, 95% CI 0.93–2.10 comparing 10+ g/d vs. 0.1–4.9 g/d), but no associations were observed for wine and beer consumption.

Conclusion

These results suggest no association of alcohol consumption with the risk of pancreatic cancer.

Keywords

Ethanol Pancreatic cancer Epidemiology EPIC

Copyright information

© Springer Science+Business Media B.V. 2009