Cancer Causes & Control

, Volume 20, Issue 4, pp 487–490

Genetic variants in frizzled-related protein (FRZB) and the risk of colorectal neoplasia

  • Sonja I. Berndt
  • Wen-Yi Huang
  • Meredith Yeager
  • Joel L. Weissfeld
  • Stephen J. Chanock
  • Richard B. Hayes
Brief Report

DOI: 10.1007/s10552-008-9274-y

Cite this article as:
Berndt, S.I., Huang, W., Yeager, M. et al. Cancer Causes Control (2009) 20: 487. doi:10.1007/s10552-008-9274-y

Abstract

Objective

The Wnt/APC/β-catenin signaling pathway, which includes frizzled-related protein (FRZB), plays a critical role in the development of colorectal cancer, and recent evidence suggests that the functional polymorphism, FRZB Arg324Gly, may be associated with risk for this disease. To determine if this finding could be replicated, we investigated the association between two FRZB polymorphisms (Arg324Gly and Arg200Trp) and the risk of colorectal adenoma and cancer in nested case–control studies.

Methods

Participants consisted of 1,709 adenoma cases, 620 cancer cases, and 1,849 controls within the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CI) for the associations with colorectal neoplasia.

Results

No association was observed for either polymorphism or any haplotypes with colorectal adenoma or colorectal cancer (p > 0.05 for all).

Conclusion

Our study does not support the previously observed association between the FRZB 324Gly variant and colorectal cancer risk. However, further study of additional genetic variants within this pathway is still warranted, given the important role of the Wnt signaling pathway in colorectal carcinogenesis.

Keywords

Colorectal adenomaColorectal cancerPolymorphismWnt signaling pathway

Abbreviations

OR

Odds ratio

95% CI

95% confidence interval

SNP

Single nucleotide polymorphism

PLCO

Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial

Supplementary material

10552_2008_9274_MOESM1_ESM.pdf (109 kb)
(PDF 77 kb)

Copyright information

© National Cancer Institute 2008

Authors and Affiliations

  • Sonja I. Berndt
    • 1
  • Wen-Yi Huang
    • 1
  • Meredith Yeager
    • 1
    • 2
  • Joel L. Weissfeld
    • 3
  • Stephen J. Chanock
    • 1
  • Richard B. Hayes
    • 1
  1. 1.Division of Cancer Epidemiology & GeneticsNational Cancer InstituteBethesdaUSA
  2. 2.Advanced Technology Program, SAIC-Frederick, Inc.National Cancer Institute FrederickFrederickUSA
  3. 3.University of PittsburghPittsburghUSA