Cancer Causes & Control

, Volume 19, Issue 10, pp 1209–1215

Dietary intake of carotenoids and retinol and endometrial cancer risk in an Italian case–control study

  • Claudio Pelucchi
  • Luigino Dal Maso
  • Maurizio Montella
  • Maria Parpinel
  • Eva Negri
  • Renato Talamini
  • Aldo Giudice
  • Silvia Franceschi
  • Carlo La Vecchia
Original Paper

DOI: 10.1007/s10552-008-9190-1

Cite this article as:
Pelucchi, C., Dal Maso, L., Montella, M. et al. Cancer Causes Control (2008) 19: 1209. doi:10.1007/s10552-008-9190-1

Abstract

Objectives

To provide information on the relation between intake of carotenoids and retinol and endometrial cancer, since available data are inconsistent. Further, carotenoids other than beta-carotene have been rarely investigated.

Methods

We conducted a multi-centric case–control study in various areas of Italy between 1992 and 2006 on 454 women with incident, histologically confirmed endometrial cancer and 908 controls admitted to the same network of hospitals of cases for acute, non-neoplastic conditions. Intake of carotenoids and retinol was computed from a validated and reproducible food frequency questionnaire. We adjusted for selected covariates, including energy intake, and calculated multivariate odds ratios (OR) and 95% confidence intervals (CI) using conditional logistic regression.

Results

Comparing the highest to the lowest quartile of intake, the ORs of endometrial cancer were 0.69 (95% CI, 0.48–0.99) for beta-carotene, 0.65 (95% CI, 0.45–0.94) for beta-cryptoxanthin, and 0.59 (95% CI, 0.41–0.85) for lutein plus zeaxanthin intake. No association emerged with retinol (OR = 1.31, 95% CI, 0.94–1.84), alpha-carotene (OR = 0.94, 95% CI, 0.66–1.34), and lycopene (OR = 0.95, 95% CI, 0.68–1.34).

Conclusions

Our results support a favorable role of selected dietary carotenoids on endometrial cancer risk.

Keywords

CarotenoidsCase–control studyDietEndometrial neoplasmsEpidemiologic studies

Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Claudio Pelucchi
    • 1
  • Luigino Dal Maso
    • 2
  • Maurizio Montella
    • 3
  • Maria Parpinel
    • 4
  • Eva Negri
    • 1
  • Renato Talamini
    • 2
  • Aldo Giudice
    • 3
  • Silvia Franceschi
    • 5
  • Carlo La Vecchia
    • 1
    • 6
  1. 1.Istituto di Ricerche Farmacologiche “Mario Negri”MilanItaly
  2. 2.Unità di Epidemiologia e BiostatisticaCentro di Riferimento OncologicoAviano (PN)Italy
  3. 3.Unità di EpidemiologiaIstituto Nazionale Tumori “Fondazione Giovanni Pascale”NaplesItaly
  4. 4.Istituto di Igiene ed Epidemiologia, DPMSCUniversità degli Studi di UdineUdineItaly
  5. 5.International Agency for Research on CancerLyonFrance
  6. 6.Istituto di Statistica Medica e Biometria “G. A. Maccacaro”Università degli Studi di MilanoMilanItaly