Cancer Causes & Control

, Volume 19, Issue 10, pp 1401–1407

Cancer incidence among pesticide applicators exposed to captan in the Agricultural Health Study

Authors

  • David L. Greenburg
    • Department of Medicine-EDPUniformed Services University of the Health Sciences
    • Department of Medicine-EDPUniformed Services University of the Health Sciences
    • Division of Cancer Epidemiology and Genetics, Department of Health and Human ServicesNational Cancer Institute, National Institutes of Health
  • Stella Koutros
    • Division of Cancer Epidemiology and Genetics, Department of Health and Human ServicesNational Cancer Institute, National Institutes of Health
  • Mustafa Dosemeci
    • Division of Cancer Epidemiology and Genetics, Department of Health and Human ServicesNational Cancer Institute, National Institutes of Health
  • Rahulkumar Patel
    • Department of Medicine-EDPUniformed Services University of the Health Sciences
  • Cynthia J. Hines
    • National Institute for Occupational Safety and Health
  • Jane A. Hoppin
    • Epidemiology Branch, Department of Health and Human ServicesNational Institute of Environmental Health Sciences, National Institutes of Health
  • Michael C. R. Alavanja
    • Division of Cancer Epidemiology and Genetics, Department of Health and Human ServicesNational Cancer Institute, National Institutes of Health
Brief Report

DOI: 10.1007/s10552-008-9187-9

Cite this article as:
Greenburg, D.L., Rusiecki, J., Koutros, S. et al. Cancer Causes Control (2008) 19: 1401. doi:10.1007/s10552-008-9187-9

Abstract

Objective

Captan is a widely used antifungal pesticide whose potential to cause cancer in humans is uncertain.

Methods

We evaluated the incidence of cancer among pesticide applicators exposed to captan in the Agricultural Health Study. Detailed information on pesticide exposure and lifestyle factors was obtained from self-administered enrollment questionnaires completed between 1993 and 1997.

Results

Of the 48,986 applicators enrolled 4,383 (9%) had applied captan. Median follow-up time was 9.14 years. Poisson regression analysis was used to estimate relative risks (RR) for cancer subtypes by tertiles of captan exposure. We investigated risk for all cancers combined and sites of cancer for which at least 15 cases occurred among captan-exposed applicators. These sites included cancers of the prostate, lung, and colon, blood-related cancers, and colorectal cancers. During follow-up 2,912 incident primary cases of cancer were identified. No association between the highest tertile of captan exposure (>67.375 intensity-weighted days) and development of all cancers (RR = 0.89; 95% CI, 0.71–1.13) or cancer of any specific site was observed.

Conclusion

Although our study is limited by low numbers of observed cancer cases and follow-up time of 9.14 years, it does not provide evidence of an increased risk for the development of cancer at the investigated sites.

Keywords

CaptanCancerAgricultural Health StudyCohortProspectivePesticideFungicideCAS number 133-06-2

Copyright information

© Springer-Verlag 2008