Cancer Causes & Control

, Volume 19, Issue 8, pp 887–894

Cancer risk in a cohort of patients with systemic lupus erythematosus (SLE) in California

  • Arti Parikh-Patel
  • Richard H. White
  • Mark Allen
  • Rosemary Cress
Original Paper

DOI: 10.1007/s10552-008-9151-8

Cite this article as:
Parikh-Patel, A., White, R.H., Allen, M. et al. Cancer Causes Control (2008) 19: 887. doi:10.1007/s10552-008-9151-8

Abstract

Objective

We conducted a retrospective cohort study to examine cancer risk in a large cohort of systemic lupus erythematosus (SLE) patients in California.

Methods

The cohort consisted of individuals with SLE derived from statewide patient discharge data during the period 1991–2002. SLE patients were followed using cancer registry data to examine patterns of cancer development. Standardized incidence ratios (SIRs) and 95% CI were calculated to compare the observed to expected numbers of cancers based on age-, race-, and sex-specific incidence rates in the California population.

Results

The 30,478 SLE patients were observed for 157,969 person-years. A total of 1,273 cancers occurred within the observation interval. Overall cancer risk was significantly elevated (SIR = 1.14, 95% CI = 1.07–1.20). SLE patients had higher risks of vagina/vulva (SIR = 3.27, 95% CI = 2.41–4.31) and liver cancers (SIR = 2.70, 95% CI = 1.54–4.24). Elevated risks of lung, kidney, and thyroid cancers and several hematopoietic malignancies were also observed. Individuals had significantly lower risks of several screenable cancers, including breast, cervix, and prostate.

Conclusions

These data suggest that risks of several cancer types are elevated among SLE patients. Detailed studies of endogenous and exogenous factors that drive these associations are needed.

Keywords

CancerSystemic lupus erythematosusMalignancyAutoimmune diseasesHematologic neoplasms

Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Arti Parikh-Patel
    • 1
  • Richard H. White
    • 2
  • Mark Allen
    • 1
  • Rosemary Cress
    • 1
    • 3
  1. 1.California Cancer RegistryPublic Health InstituteSacramentoUSA
  2. 2.Department of Internal MedicineUniversity of California Davis School of MedicineSacramentoUSA
  3. 3.Department of Public Health SciencesUniversity of CaliforniaDavisUSA