Cancer Causes & Control

, Volume 19, Issue 7, pp 689–701

Smoking and gastric cancer: systematic review and meta-analysis of cohort studies

  • Ricardo Ladeiras-Lopes
  • Alexandre Kirchhofer Pereira
  • Amanda Nogueira
  • Tiago Pinheiro-Torres
  • Isabel Pinto
  • Ricardo Santos-Pereira
  • Nuno Lunet
Original Paper

DOI: 10.1007/s10552-008-9132-y

Cite this article as:
Ladeiras-Lopes, R., Pereira, A.K., Nogueira, A. et al. Cancer Causes Control (2008) 19: 689. doi:10.1007/s10552-008-9132-y

Abstract

Objective

We conducted a systematic review of studies addressing the relation between cigarette smoking and gastric cancer to estimate the magnitude of the association for different levels of exposure and cancer locations.

Methods

Published cohort, case–cohort, and nested case–control studies were identified through PubMed, Scopus, and Web of Science searches, from inception to July 2007. Relative risk (RR) estimates referring to the comparison of two categories of exposure (e.g., current smokers vs. never smokers) were combined using a random effects model. Generalized least squares regression was used for trend estimation. Heterogeneity was quantified using the I2 statistic.

Results

Forty-two articles were considered for the systematic review. Comparing current smokers with never smokers: the summary RR estimates were 1.62 in males (95% CI: 1.50–1.75; I2 = 46.0%; 18 studies) and 1.20 in females (95% CI: 1.01–1.43; I2 = 49.8%; nine studies); the RR increased from 1.3 for the lowest consumptions to 1.7 for the smoking of approximately 30 cigarettes per day in the trend estimation analysis; smoking was significantly associated with both cardia (RR = 1.87; 95% CI: 1.31–2.67; I2 = 73.2%; nine studies) and non-cardia (RR = 1.60; 95% CI: 1.41–1.80; I2 = 18.9%; nine studies) cancers.

Conclusion

Our study provides solid evidence to classify smoking as the most important behavioral risk factor for gastric cancer.

Keywords

Stomach neoplasmsSmokingMeta-analysisCohort studies

Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Ricardo Ladeiras-Lopes
    • 1
  • Alexandre Kirchhofer Pereira
    • 1
  • Amanda Nogueira
    • 1
  • Tiago Pinheiro-Torres
    • 1
  • Isabel Pinto
    • 1
  • Ricardo Santos-Pereira
    • 1
  • Nuno Lunet
    • 1
    • 2
  1. 1.Department of Hygiene and EpidemiologyPorto University Medical SchoolPortoPortugal
  2. 2.Serviço de Higiene e Epidemiologia, Faculdade de MedicinaUniversidade do PortoPortoPortugal