Cancer Causes & Control

, Volume 19, Issue 4, pp 421–429

The changing patterns of bladder cancer in Egypt over the past 26 years

  • Ashley S. Felix
  • Amr S. Soliman
  • Hussein Khaled
  • Mohamed S. Zaghloul
  • Mousumi Banerjee
  • Manal El-Baradie
  • Mohamed El-Kalawy
  • Alaa A. Abd-Elsayed
  • Kadry Ismail
  • Ahmed Hablas
  • Ibrahim A. Seifeldin
  • Mohamed Ramadan
  • Mark L. Wilson
Original Paper

DOI: 10.1007/s10552-007-9104-7

Cite this article as:
Felix, A.S., Soliman, A.S., Khaled, H. et al. Cancer Causes Control (2008) 19: 421. doi:10.1007/s10552-007-9104-7

Abstract

Objective

To evaluate temporal changes in histopathological types of bladder cancer and to assess associated changes in demographic, epidemiologic, and lifestyle risk factors.

Methods

We abstracted data from all available medical records from the National Cancer Institute of Cairo University (NCI-Cairo). Six calendar years representing 5-year periods between 1980 and 2005 were evaluated. Information on demographics, schistosomal infection, clinical symptoms of bladder cancer, and tumor pathology was abstracted.

Results

During this 26-year period, important changes in the frequency of histopathological types of bladder cancer occurred. We found a statistically significant association between time period of diagnosis and histopathological type. Patients diagnosed in 2005 had a sixfold higher odds associated with transitional cell carcinoma compared to those patients diagnosed in 1980 (odds ratio (OR) 6.00 (95% CI 4.00–8.97)).

Conclusions

These data strongly suggest that the histopathological profile of bladder cancer in Egypt has changed significantly over the past 26 years. Historically, squamous cell carcinoma was the predominant form of bladder cancer in Egypt; however transitional cell carcinoma has become the most frequent type. These results corroborate findings from a few small-scale hospital-based studies which conclude that the etiology of bladder cancer in Egypt has changed significantly over the past 26 years.

Keywords

Bladder cancerSchistosomiasisHistopathologyEpidemiologic trendsEgypt

Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Ashley S. Felix
    • 1
  • Amr S. Soliman
    • 1
  • Hussein Khaled
    • 2
  • Mohamed S. Zaghloul
    • 2
    • 3
  • Mousumi Banerjee
    • 4
  • Manal El-Baradie
    • 2
  • Mohamed El-Kalawy
    • 2
  • Alaa A. Abd-Elsayed
    • 5
  • Kadry Ismail
    • 6
  • Ahmed Hablas
    • 6
  • Ibrahim A. Seifeldin
    • 6
  • Mohamed Ramadan
    • 6
  • Mark L. Wilson
    • 1
  1. 1.Department of Epidemiology, School of Public HealthUniversity of MichiganAnn ArborUSA
  2. 2.The National Cancer InstituteCairo UniversityCairoEgypt
  3. 3.Minia Cancer CenterMinaEgypt
  4. 4.Department of Biostatistics, School of Public HealthUniversity of MichiganAnn ArborUSA
  5. 5.Department of Public Health and Biostatistics, Faculty of MedicineAssiut UniversityAssiutEgypt
  6. 6.Gharbiah Population-based Cancer RegistryTantaEgypt