Cancer Causes & Control

, Volume 19, Issue 3, pp 317–328

Analysis of lung cancer incidence in the nurses’ health and the health professionals’ follow-up studies using a multistage carcinogenesis model

  • Rafael Meza
  • William D. Hazelton
  • Graham A. Colditz
  • Suresh H. Moolgavkar
Original Paper

DOI: 10.1007/s10552-007-9094-5

Cite this article as:
Meza, R., Hazelton, W.D., Colditz, G.A. et al. Cancer Causes Control (2008) 19: 317. doi:10.1007/s10552-007-9094-5

Abstract

We analyzed lung cancer incidence among non-smokers, continuing smokers, and ex-smokers in the Nurses Health Study (NHS) and the Health Professionals Follow-Up Study (HPFS) using the two-stage clonal expansion (TSCE) model. Age-specific lung cancer incidence rates among non-smokers are identical in the two cohorts. Within the framework of the model, the main effect of cigarette smoke is on the promotion of partially altered cells on the pathway to cancer. Smoking-related promotion is somewhat higher among women, whereas smoking-related malignant conversion is somewhat lower. In both cohorts the relative risk for a given daily level of smoking is strongly modified by duration. Among smokers, the incidence in NHS relative to that in HPFS depends both on smoking intensity and duration. The age-adjusted risk is somewhat larger in NHS, but not significantly so. After smokers quit, the risk decreases over a period of many years and the temporal pattern of the decline is similar to that reported in other recent studies. Among ex-smokers, the incidence in NHS relative to that in HPFS depends both on previous levels of smoking and on time since quitting. The age-adjusted risk among ex-smokers is somewhat higher in NHS, possibly due to differences in the age-distribution between the two cohorts.

Keywords

Lung cancer epidemiologyLung cancer age-specific incidenceNever smokers lung cancer riskSmokers relative riskEx-smokers relative riskMultistage carcinogenesisTwo-stage clonal expansion model

Supplementary material

10552_2007_9094_MOESM1_ESM.pdf (9 kb)
Two-stage clonal expansion model (10 KB)

Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  • Rafael Meza
    • 1
  • William D. Hazelton
    • 1
  • Graham A. Colditz
    • 2
    • 3
  • Suresh H. Moolgavkar
    • 1
  1. 1.Division of Public Health SciencesFred Hutchinson Cancer Research CenterSeattleUSA
  2. 2.Channing LaboratoryBrigham and Women’s Hospital and Harvard Medical SchoolBostonUSA
  3. 3.Siteman Cancer CenterWashington University Medical SchoolSt. LouisUSA