Cancer Causes & Control

, Volume 18, Issue 9, pp 989–999

Sun exposure, vitamin D receptor gene polymorphisms and risk of non-Hodgkin lymphoma

  • Mark P. Purdue
  • Patricia Hartge
  • Scott Davis
  • James R. Cerhan
  • Joanne S. Colt
  • Wendy Cozen
  • Richard K. Severson
  • Yan Li
  • Stephen J. Chanock
  • Nathaniel Rothman
  • Sophia S. Wang
Original Paper

DOI: 10.1007/s10552-007-9039-z

Cite this article as:
Purdue, M.P., Hartge, P., Davis, S. et al. Cancer Causes Control (2007) 18: 989. doi:10.1007/s10552-007-9039-z

Abstract

Objective

Recent findings suggest that ultraviolet (UV) radiation exposure may reduce risk of developing non-Hodgkin lymphoma (NHL), but the biologic basis for this relationship remains unclear. We analyzed data from our US population-based case–control study of NHL to investigate whether our previously reported inverse association with sun exposure was dependent upon variants in the vitamin D receptor gene (IVS10 + 283G > A (BsmI), Ex11 + 32T > C (TaqI)), and genes linked to UV-induced immune modulation (IL4, IL10, IL12A, IL12B, TNF).

Methods

UV exposure data was collected from an in-person interview with 551 cases and 462 controls. We calculated odds ratios (OR) and 95% confidence intervals (CI) for sun exposure measures for joint variant-exposure effects.

Results

The association with NHL risk for time in the midday sun within the last decade was dependent upon Ex11 + 32 T > C genotype. Compared to TT carriers who reported < 7 h/week of sun exposure, CC subjects with < 7 h/week of sun exposure had an increased risk of NHL (OR = 1.9, 95% CI 0.8–4.4, Pinteraction = 0.16), while the relative risks for other CC carriers approached unity with increasing level of sun exposure. This pattern of effects was especially apparent for follicular lymphoma (for CC genotype and < 7 h/week of exposure: OR 6.3, 95% CI 1.9–22, Pinteraction = 0.004), and was consistently observed across measures of reported sun exposure for different periods of life. As IVS10 + 283G > A is correlated with Ex11 + 32T > C in our population (r2 = 0.95), results were equivalent for those with the IVS10 + 283 AA genotype. No evidence of interaction with cytokine gene variants was observed.

Conclusions

Our results suggest that the inverse association between UV exposure and NHL risk may be mediated by the vitamin D pathway. Further investigation of this finding in other studies is warranted.

Keywords

Non-Hodgkin lymphoma Vitamin D Polymorphism  Genetic Sunlight 

Copyright information

© Springer Science + Business Media B.V. 2007

Authors and Affiliations

  • Mark P. Purdue
    • 1
    • 2
  • Patricia Hartge
    • 1
    • 2
  • Scott Davis
    • 3
  • James R. Cerhan
    • 4
  • Joanne S. Colt
    • 1
    • 2
  • Wendy Cozen
    • 5
  • Richard K. Severson
    • 6
  • Yan Li
    • 1
    • 2
  • Stephen J. Chanock
    • 7
  • Nathaniel Rothman
    • 1
    • 2
  • Sophia S. Wang
    • 1
    • 2
  1. 1.Division of Cancer Epidemiology and GeneticsNational Cancer InstituteRockvilleUSA
  2. 2.Department of Health and Human ServicesNational Institutes of HealthRockvilleUSA
  3. 3.Program in Epidemiology, Fred Hutchinson Cancer Research Center and Department of EpidemiologyUniversity of WashingtonSeattleUSA
  4. 4.Department of Health Sciences ResearchMayo Clinic College of MedicineRochesterUSA
  5. 5.Department of Preventive Medicine, Norris Comprehensive Cancer CenterUniversity of Southern California School of MedicineLos AngelesUSA
  6. 6.Department of Family Medicine and Karmanos Cancer InstituteWayne State UniversityDetroitUSA
  7. 7.Department of Health and Human ServicesNCI Core Genotyping Facility, National Cancer Institute, National Institutes of HealthGaithersburgUSA

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