Cancer Causes & Control

, Volume 18, Issue 7, pp 687–703

Dietary lipids and endometrial cancer: the current epidemiologic evidence

  • Elisa V. Bandera
  • Lawrence H. Kushi
  • Dirk F. Moore
  • Dina M. Gifkins
  • Marjorie L. McCullough
Review Article

DOI: 10.1007/s10552-007-9021-9

Cite this article as:
Bandera, E.V., Kushi, L.H., Moore, D.F. et al. Cancer Causes Control (2007) 18: 687. doi:10.1007/s10552-007-9021-9



Because dietary fat has been postulated to affect obesity and estrogen levels, two important risk factors for endometrial cancer, its association with this disease has received some attention. We summarize here the current evidence for several dietary lipids.


Searches were conducted to identify peer-reviewed manuscripts up to December 2006. Two cohort studies and nine case–control studies were included in meta-analyses.


Random-effects summary estimates for case–control studies were 1.24 (95% CI: 1.10, 1.41) per 10% kcal from total fat and 1.28 (95% CI: 1.12, 1.47) per 10 g/1,000 kcal of saturated fat. The only cohort study evaluating total fat and saturated fat did not find an association. We estimated a 35% increased risk (95% CI: 0.96, 1.90) per 150 mg/1,000 kcal of cholesterol intake, based on six case–control studies. For animal fat (per 10 g/1,000 kcal) the summary estimates were 0.78 (95% CI: 0.63, 0.96) and 1.34 (95% CI: 1.06, 1.69) for two cohort and four case–control studies, respectively.


Case–control data suggest an increased risk for total, saturated, and animal fat. However, the limited available cohort data do not support these associations. Additional data, particularly from prospective studies, are needed before conclusions can be drawn.


Endometrial carcinoma Diet Fat Saturated fat Cholesterol Meta-analysis Systematic literature review 



World Cancer Research Fund International


American Institute for Cancer Research


Systematic Literature Review


Odds ratio


Relative risk


Confidence interval


Food frequency questionnaire


Body mass index


Hormone replacement therapy

Copyright information

© Springer Science + Business Media B.V. 2007

Authors and Affiliations

  • Elisa V. Bandera
    • 1
    • 3
  • Lawrence H. Kushi
    • 2
  • Dirk F. Moore
    • 3
  • Dina M. Gifkins
    • 1
    • 3
  • Marjorie L. McCullough
    • 4
  1. 1.The Cancer Institute of New JerseyRobert Wood Johnson Medical SchoolNew BrunswickUSA
  2. 2.Division of ResearchKaiser PermanenteOaklandUSA
  3. 3.School of Public HealthUniversity of Medicine and Dentistry of New JerseyPiscatawayUSA
  4. 4.Epidemiology and Surveillance ResearchAmerican Cancer SocietyAtlantaUSA

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