Cancer Causes & Control

, Volume 18, Issue 7, pp 687–703

Dietary lipids and endometrial cancer: the current epidemiologic evidence

  • Elisa V. Bandera
  • Lawrence H. Kushi
  • Dirk F. Moore
  • Dina M. Gifkins
  • Marjorie L. McCullough
Review Article

DOI: 10.1007/s10552-007-9021-9

Cite this article as:
Bandera, E.V., Kushi, L.H., Moore, D.F. et al. Cancer Causes Control (2007) 18: 687. doi:10.1007/s10552-007-9021-9

Abstract

Background

Because dietary fat has been postulated to affect obesity and estrogen levels, two important risk factors for endometrial cancer, its association with this disease has received some attention. We summarize here the current evidence for several dietary lipids.

Methods

Searches were conducted to identify peer-reviewed manuscripts up to December 2006. Two cohort studies and nine case–control studies were included in meta-analyses.

Results

Random-effects summary estimates for case–control studies were 1.24 (95% CI: 1.10, 1.41) per 10% kcal from total fat and 1.28 (95% CI: 1.12, 1.47) per 10 g/1,000 kcal of saturated fat. The only cohort study evaluating total fat and saturated fat did not find an association. We estimated a 35% increased risk (95% CI: 0.96, 1.90) per 150 mg/1,000 kcal of cholesterol intake, based on six case–control studies. For animal fat (per 10 g/1,000 kcal) the summary estimates were 0.78 (95% CI: 0.63, 0.96) and 1.34 (95% CI: 1.06, 1.69) for two cohort and four case–control studies, respectively.

Conclusions

Case–control data suggest an increased risk for total, saturated, and animal fat. However, the limited available cohort data do not support these associations. Additional data, particularly from prospective studies, are needed before conclusions can be drawn.

Keywords

Endometrial carcinoma Diet Fat Saturated fat Cholesterol Meta-analysis Systematic literature review 

Abbreviations

WCRF

World Cancer Research Fund International

AICR

American Institute for Cancer Research

SLR

Systematic Literature Review

OR

Odds ratio

RR

Relative risk

CI

Confidence interval

FFQ

Food frequency questionnaire

BMI

Body mass index

HRT

Hormone replacement therapy

Copyright information

© Springer Science + Business Media B.V. 2007

Authors and Affiliations

  • Elisa V. Bandera
    • 1
    • 3
  • Lawrence H. Kushi
    • 2
  • Dirk F. Moore
    • 3
  • Dina M. Gifkins
    • 1
    • 3
  • Marjorie L. McCullough
    • 4
  1. 1.The Cancer Institute of New JerseyRobert Wood Johnson Medical SchoolNew BrunswickUSA
  2. 2.Division of ResearchKaiser PermanenteOaklandUSA
  3. 3.School of Public HealthUniversity of Medicine and Dentistry of New JerseyPiscatawayUSA
  4. 4.Epidemiology and Surveillance ResearchAmerican Cancer SocietyAtlantaUSA

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