Cancer Causes & Control

, Volume 18, Issue 4, pp 361–373

Alcohol intake and breast cancer risk: the European Prospective Investigation into Cancer and Nutrition (EPIC)

Authors

    • Institute of Cancer Epidemiology, Danish Cancer Society
  • Jane Christensen
    • Institute of Cancer Epidemiology, Danish Cancer Society
  • Anja Olsen
    • Institute of Cancer Epidemiology, Danish Cancer Society
  • Connie Stripp
    • Institute of Cancer Epidemiology, Danish Cancer Society
  • Birthe L. Thomsen
    • Institute of Cancer Epidemiology, Danish Cancer Society
  • Kim Overvad
    • Department of Clinical EpidemiologyAalborg Hospital and Aarhus University Hospital
  • Petra H. M. Peeters
    • Julius Center for Health Sciences and Primary CareUniversity Medical Center
  • Carla H. van Gils
    • Julius Center for Health Sciences and Primary CareUniversity Medical Center
  • H. Bas Bueno-de-Mesquita
    • National Institute for Public Health and the Environment
  • Marga C. Ocké
    • National Institute for Public Health and the Environment
  • Anne Thiebaut
    • INSERM, ERI-20, Institut Gustave Roussy
  • Agnès Fournier
    • INSERM, ERI-20, Institut Gustave Roussy
  • Françoise Clavel-Chapelon
    • INSERM, ERI-20, Institut Gustave Roussy
  • Franco Berrino
    • Epidemiology UnitNational Cancer Institute
  • Domenico Palli
    • Molecular and Nutritional Epidemiology UnitCSPO-Scientific Institute of Tuscany
  • Rosario Tumino
    • Cancer RegistryAzienda Ospedaliera “Civile-M.P. Arezzo”
  • Salvatore Panico
    • Department of Clinical and Experimental MedicineFederico II University
  • Paolo Vineis
    • Cancer Epidemiology DepartmentUniversity of Turin
    • Imperial College
  • Antonio Agudo
    • Unit of EpidemiologyCatalan Institute of Oncology
  • Eva Ardanaz
    • Public Health Institute of Navarra
  • Carmen Martinez-Garcia
    • Andalusian School of Public Health
  • Pilar Amiano
    • Department of Public Health of Guipuzkoa
  • Carmen Navarro
    • Epidemiology DepartmentRegional Health Council
  • José R. Quirós
    • Health Information Unit, Public Health and Planning Directorate, Health and Health Services CouncilPrincipality of Asturias
  • Tim J. Key
    • Epidemiology Unit, Cancer Research UKOxford University
  • Gillian Reeves
    • Epidemiology Unit, Cancer Research UKOxford University
  • Kay-Tee Khaw
    • Department of Public Health and Primary Care, School of Clinical MedicineUniversity of Cambridge
  • Sheila Bingham
    • MRC Dunn Human Nutrition UnitWelcome Trust/MRC Building
  • Antonia Trichopoulou
    • Department of Hygiene and Epidemiology, School of MedicineUniversity of Athens
  • Dimitrios Trichopoulos
    • Department of Hygiene and Epidemiology, School of MedicineUniversity of Athens
  • Androniki Naska
    • Department of Hygiene and Epidemiology, School of MedicineUniversity of Athens
  • Gabriele Nagel
    • Division of Clinical EpidemiologyGerman Cancer Research Center
  • Jenny Chang-Claude
    • Division of Clinical EpidemiologyGerman Cancer Research Center
  • Heiner Boeing
    • Department of EpidemiologyGerman Institute of Human Nutrition Potsdam-Rehbrücke
  • Petra H. Lahmann
    • Department of EpidemiologyGerman Institute of Human Nutrition Potsdam-Rehbrücke
  • Jonas Manjer
    • Department of SurgeryMalmö University Hospital
  • Elisabet Wirfält
    • Department of Clinical SciencesLund University
  • Göran Hallmans
    • Public Health and Clinical Medicine, Nutritional ResearchUniversity Hospital of Northern Sweden
  • Ingegerd Johansson
    • Public Health and Clinical Medicine, Nutritional ResearchUniversity Hospital of Northern Sweden
  • Eiliv Lund
    • Institute of Community MedicineUniversity of Tromsø
  • Guri Skeie
    • Institute of Community MedicineUniversity of Tromsø
  • Anette Hjartåker
    • Cancer Registry of NorwayInstitute of Population-based Cancer Research
  • Pietro Ferrari
    • Nutrition and Hormones GroupInternational Agency for Research on Cancer
  • Nadia Slimani
    • Nutrition and Hormones GroupInternational Agency for Research on Cancer
  • Rudolf Kaaks
    • Nutrition and Hormones GroupInternational Agency for Research on Cancer
  • Elio Riboli
    • Department of Epidemiology & Public Health, Faculty of MedicineImperial College
Original Paper

DOI: 10.1007/s10552-006-0112-9

Cite this article as:
Tjønneland, A., Christensen, J., Olsen, A. et al. Cancer Causes Control (2007) 18: 361. doi:10.1007/s10552-006-0112-9

Abstract

Objective

Most epidemiologic studies have suggested an increased risk of breast cancer with increasing alcohol intake. Using data from 274,688 women participating in the European Prospective Investigation into Cancer and Nutrition study (EPIC), we investigated the relation between alcohol intake and the risk of breast cancer.

Methods

Incidence rate ratios (IRRs) based on Cox proportional hazard models were calculated using reported intake of alcohol, recent (at baseline) and lifetime exposure. We adjusted for known risk factors and stratified according to study center as well as potentially modifying host factors.

Results

During 6.4 years of follow up, 4,285 invasive cases of breast cancer within the age group 35–75 years were identified. For all countries together the IRR per 10 g/day higher recent alcohol intake (continuous) was 1.03 (95% confidence interval (CI): 1.01–1.05). When adjusted, no association was seen between lifetime alcohol intake and risk of breast cancer. No difference in risk was shown between users and non-users of HRT, and there was no significant interaction between alcohol intake and BMI, HRT or dietary folate.

Conclusion

This large European study supports previous findings that recent alcohol intake increases the risk of breast cancer.

Keywords

AlcoholBreast neoplasmCohort studyHormone replacement therapy

Abbreviations

BMI

Body mass index

IRR

Incidence rate ratio

CI

Confidence interval

EPIC

European Prospective Investigation into Cancer and Nutrition

HRT

Hormone replacement therapy

Pre

Premenopausal

Peri

Perimenopausal

Post

Postmenopausal

PY

Person years

Copyright information

© Springer Science+Business Media B.V. 2007