Cancer Causes & Control

, Volume 17, Issue 10, pp 1237–1244

Sex steroid hormones in young manhood and the risk of subsequent prostate cancer: a longitudinal study in African-Americans and Caucasians (United States)

  • Chiaojung J. Tsai
  • Barbara A. Cohn
  • Piera M. Cirillo
  • David Feldman
  • Frank Z. Stanczyk
  • Alice S. Whittemore
Original Paper

DOI: 10.1007/s10552-006-0052-4

Cite this article as:
Tsai, C.J., Cohn, B.A., Cirillo, P.M. et al. Cancer Causes Control (2006) 17: 1237. doi:10.1007/s10552-006-0052-4

Abstract

Objective

To investigate the relation of sex hormone levels in young adults to subsequent prostate cancer risk.

Methods

From 1959 to 1967, the Child Health and Development Studies collected sera from 10,442 men (median age: 34 years) and followed them for a median of 32 years. In this analysis, we selected 119 African-Americans and 206 Caucasians diagnosed with prostate cancer during the follow-up period. Two prostate cancer-free men were chosen to match each prostate cancer case on race and birth year. We compared the levels of testosterone, estradiol, and sex hormone-binding globulin in cases to those of their matched controls using conditional logistic regression.

Results

There was no significant association between absolute levels of sex hormones in youth and prostate cancer risk in either race. However, among Caucasians, but not African-Americans, prostate cancer risk was positively associated with the ratio of total testosterone to total estradiol (odds ratio relating the fourth to the first quartile: 3.01; 95% confidence interval: 1.42–6.39).

Conclusions

The association between testosterone to estradiol ratio and prostate cancer risk in young Caucasians is consistent with similar findings in older Caucasians. The absence of this association in African-Americans needs confirmation in other data involving larger numbers of African-Americans.

Keywords

African-AmericanCaucasianProspective studyProstate cancerTestosteroneEstrogenSteroid hormone

Copyright information

© Springer Science+Business Media B.V. 2006

Authors and Affiliations

  • Chiaojung J. Tsai
    • 1
  • Barbara A. Cohn
    • 2
  • Piera M. Cirillo
    • 2
  • David Feldman
    • 3
  • Frank Z. Stanczyk
    • 4
  • Alice S. Whittemore
    • 1
  1. 1.Department of Health Research and PolicyStanford University School of MedicineStanfordUSA
  2. 2.Center for Research on Women’s and Children’s HealthChild Health and Development Studies, Public Health InstituteBerkeleyUSA
  3. 3.Department of Medicine, Division of Endocrinology, Gerontology and MetabolismStanford University School of MedicineStanfordUSA
  4. 4.Department of Medicine, Division of Reproductive Endocrinology and InfertilityUniversity of Southern CaliforniaLos AngelesUSA