Cancer Causes & Control

, 17:793

MTHFR (C677T and A1298C) Polymorphisms and Risk of Sporadic Distal Colorectal Adenoma in the UK Flexible Sigmoidoscopy Screening Trial (United Kingdom)

  • Panagiota N. Mitrou
  • Mark A. Watson
  • Alexandre S. Loktionov
  • Christopher Cardwell
  • Marc J. Gunter
  • Wendy S. Atkin
  • Christopher P. Macklin
  • Tom Cecil
  • Timothy D. Bishop
  • John Primrose
  • Sheila A. Bingham
Original Paper

DOI: 10.1007/s10552-006-0016-8

Cite this article as:
Mitrou, P.N., Watson, M.A., Loktionov, A.S. et al. Cancer Causes Control (2006) 17: 793. doi:10.1007/s10552-006-0016-8

Abstract

Objective

The purpose of this study was to further evaluate the role of low activity MTHFR variants as well as to explore interactive effects between alcoholic drink consumption and MTHFR variants and risk of distal colorectal adenomatous polyps.

Methods

We examined the relationship between MTHFR C677T and A1298C gene polymorphisms and risk of distal adenomas in one of the largest case control studies of 946 polyp-free controls and 894 cases, all participants of the UK Flexible Sigmoidoscopy Screening Trial (UKFSS).

Results

Investigation of the effect of the MTHFR C677T polymorphism in this large UKFSS study revealed no overall association on adenoma risk (P>0.05). However the MTHFR 1298C allele was linked, for the first time, to high risk adenomas, although in males only (odds ratio (OR) for A/C+C/C compared with A/A 1.55; 95% confidence interval (CI), 1.08–2.22; P=0.018).

Conclusions

In this, the largest study of these polymorphisms in relation to colorectal adenoma, there was no evidence for an interaction with alcohol in combination with the variant forms of MTHFR (P>0.05).

Keywords

MTHFR polymorphismsSporadic distal colorectal adenomaUK Flexible Sigmoidoscopy Screening Trial

Copyright information

© Springer Science+Business Media B.V. 2006

Authors and Affiliations

  • Panagiota N. Mitrou
    • 1
  • Mark A. Watson
    • 2
  • Alexandre S. Loktionov
    • 1
  • Christopher Cardwell
    • 3
  • Marc J. Gunter
    • 1
  • Wendy S. Atkin
    • 3
  • Christopher P. Macklin
    • 4
  • Tom Cecil
    • 5
  • Timothy D. Bishop
    • 4
  • John Primrose
    • 5
  • Sheila A. Bingham
    • 1
  1. 1.Dunn Human Nutrition UnitMRC/Wellcome Trust BuildingCambridgeUK
  2. 2.Department of General SurgeryNorfolk and Norwich Health Care NHS TrustNorwichUK
  3. 3.Cancer Research UKSt Mark’s HospitalHarrowUK
  4. 4.Cancer Research UK Genetic Epidemiology SectionSt James’s University HospitalLeedsUK
  5. 5.Cancer Sciences DivisionUniversity of SouthamptonSouthamptonUK