, Volume 17, Issue 4, pp 483-487

Cancer and Rhythm

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In a recent editorial comment, Denise Duboule [1] emphasized that “animal development is, in fact, nothing but time.” In this issue of Cancer Causes and Control, several papers will substantiate that not only developmental, but also neoplastic processes may be linked to what Duboule [1] and Halberg [2] referred to as ‘chronomics’: timing and rhythm. Moreover, there is reason to believe that timing and rhythm may have been underappreciated in current therapeutic settings [3]. The papers in this issue of Cancer Causes and Control are from leading researchers in the field of cancer and body rhythms. Each one addresses a specific aspect of the topic, and their work is cited below in this overview editorial.

Evidence from observational studies is growing [4] that the disturbance of body rhythms, in particular, circadian disruption e.g., shift work [58] or chronic jet-lag [912] contribute significantly to the development of breast cancer. Figure 1 compares the relative impact of rhythm dist ...


This special issue of CCC is dedicated to Gunther Hildebrandt (Marburg, Germany) and Franz Halberg (Minnesota, USA), two great pioneeers of Chronobiology.