Cancer Causes & Control

, Volume 16, Issue 6, pp 755–764

Occupational exposures and risk of esophageal and gastric cardia cancers among male Swedish construction workers

  • Catarina Jansson
  • Anna L.V. Johansson
  • Ingvar A. Bergdahl
  • Paul W. Dickman
  • Nils Plato
  • Johanna Adami
  • Paolo Boffetta
  • Jesper Lagergren
Article

DOI: 10.1007/s10552-005-1723-2

Cite this article as:
Jansson, C., Johansson, A.L., Bergdahl, I.A. et al. Cancer Causes Control (2005) 16: 755. doi:10.1007/s10552-005-1723-2

Abstract

Objective: The rising incidence and the strong male predominance among patients with esophageal and gastric cardia adenocarcinoma remain unexplained. We hypothesized that occupational airborne exposures in a traditional male dominated industry might contribute to these observations.

Methods: A prospective, large cohort study of Swedish construction workers was linked to the Swedish population-based registers of Cancer, Causes of Death and Total Population. 260,052 men were followed from 1971 through 2000. Industrial hygienists assessed specific exposures for 200 job titles, and occupational airborne exposures were analyzed separately and combined. Incidence rate ratios (IRR), with 95% confidence intervals (CI), were estimated in multivariable Cox regression models adjusted for attained age, calendar period, smoking status and body mass.

Results: We found positive associations between high exposure to asbestos (IRR 4.5 [95% CI 1.4–14.3]) and cement dust (IRR 3.8 [95% CI 1.5–9.6]) and risk of esophageal adenocarcinoma. Associations were seen between high exposure to asphalt fumes (IRR 2.3 [95% CI 1.0–5.3]) and wood dust (IRR 4.8 [95% CI 1.2–19.4]) and risk of cardia adenocarcinoma. No consistent associations regarding esophageal squamous-cell carcinoma were found.

Conclusions: Exposure to asbestos and cement dust may be risk factors for esophageal adenocarcinoma, and exposure to asphalt fumes and wood dust may increase the risk of cardia adenocarcinoma. However, these associations cannot explain the major sex differences or the increasing incidence trends of these tumors.

Keywords

adenocarcinoma cardia cancer construction workers esophageal cancer occupational exposures 

Copyright information

© Springer 2005

Authors and Affiliations

  • Catarina Jansson
    • 1
  • Anna L.V. Johansson
    • 1
  • Ingvar A. Bergdahl
    • 2
  • Paul W. Dickman
    • 1
  • Nils Plato
    • 3
  • Johanna Adami
    • 4
  • Paolo Boffetta
    • 1
    • 5
  • Jesper Lagergren
    • 1
    • 6
  1. 1.Department of Medical Epidemiology and BiostatisticsKarolinska InstitutetStockholmSweden
  2. 2.Occupational Medicine, Department of Clinical Medicine and Public HealthUmeå UniversityUmeåSweden
  3. 3.Division of Occupational Health, Department of Public Health SciencesKarolinska InstitutetStockholmSweden
  4. 4.Clinical Epidemiology Unit, Department of MedicineKarolinska University HospitalStockholmSweden
  5. 5.International Agency for Research on CancerLyonFrance
  6. 6.Department of Surgical SciencesKarolinska InstitutetStockholmSweden

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