Cancer Causes & Control

, Volume 17, Issue 5, pp 655–662

Cancer and Laterality: A Study of The Five Major Paired Organs (UK)

  • Rahul Roychoudhuri
  • Venkata Putcha
  • Henrik Møller
Original Paper

DOI: 10.1007/s10552-005-0615-9

Cite this article as:
Roychoudhuri, R., Putcha, V. & Møller, H. Cancer Causes Control (2006) 17: 655. doi:10.1007/s10552-005-0615-9

Abstract

Objective

The human body displays marked asymmetry: paired organs differ bilaterally exerting effects upon cancer incidence and progression. However the factors involved remain contentious. In this large study involving over a quarter of a million cancer patients, we examine the epidemiological correlates of cancer laterality including incidence, stage at diagnosis and survival in the five major paired organs: the breasts, lungs, kidneys, testes and ovaries.

Methods

Cancer patients were selected from the Thames Cancer Registry database and age-standardised incidence rates (ASRs), stage distribution at diagnosis and survival rates computed, stratifying appropriately.

Results

Cancer incidence differed significantly by laterality at all sites studied (p<0.01) but substantially in the lung (left–right incidence-rate ratio [IRR] 0.87), breast (IRR 1.07), testis (IRR 0.87) and in ovarian cancer (IRR 0.86). Autopsy data showed strongly coincident left–right organ size ratios (0.87 in the lungs and 0.87 in the testes). Patients with left testicular cancer, right lung cancer and left ovarian cancer showed significantly better survival than those with contralateral disease (p<0.05).

Conclusions

In the lungs and testes, asymmetries in cancer incidence closely coincided with asymmetries in organ size. Our results suggest that tissue mass in these organs is an important contributor to asymmetry in cancer incidence.

Keywords

Laterality Cancer Incidence Stage Survival Asymmetry 

Copyright information

© Springer 2006

Authors and Affiliations

  • Rahul Roychoudhuri
    • 1
  • Venkata Putcha
    • 1
  • Henrik Møller
    • 1
  1. 1.Thames Cancer Registry, Division of Cancer StudiesGuy’s, King’s and St. Thomas’ School of MedicineLondonUK