Relation of Anthropometric Measurements to Ovarian Cancer Risk in a Population-based Case–control Study (United States)
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To examine the relationship between anthropometric measures and ovarian cancer by menopausal status.
We analyzed data from a population-based case–control study comprised of 700 incident cases of epithelial ovarian cancer and 5,943 population controls from Massachusetts and Wisconsin enrolled between 1993 and 2001. In a telephone interview, information was gathered on established ovarian cancer risk factors, as well as adult height and age-specific body weight. Logistic regression was used to estimate multivariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for body mass index (BMI) throughout life.
Recent BMI had no significant association with ovarian cancer risk (P-trend 0.14 for continuous BMI), after adjustment for age and other ovarian cancer risk factors. However, a non-significant positive association (overall P-trend 0.08) was observed for BMI at age 20; the risk estimate comparing a body mass of >25 kg/m2 to the lowest quintile (≤18.88 kg/m2) was moderately but non-significantly elevated (OR 1.46; 95% CI 0.92, 2.31).
Results of this study suggest that maintenance of a lean body mass, particularly in early adult life, may decrease ovarian cancer risk.
- Relation of Anthropometric Measurements to Ovarian Cancer Risk in a Population-based Case–control Study (United States)
Cancer Causes & Control
Volume 17, Issue 4 , pp 459-467
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers
- Additional Links
- Ovarian neoplasms
- Body mass index
- Risk factors
- Industry Sectors
- Author Affiliations
- 1. Department of Medicine, Division of General Internal Medicine and Public Health, Vanderbilt University School of Medicine, Medical Center East, Suite 6000, Nashville, TN, 37232-8300, USA