Cancer Causes & Control

, Volume 16, Issue 6, pp 619–635

A review: dietary and endogenously formed N-nitroso compounds and risk of childhood brain tumors

  • Marion Dietrich
  • Gladys Block
  • Janice M. Pogoda
  • Patricia Buffler
  • Stephen Hecht
  • Susan Preston -Martin
Article

DOI: 10.1007/s10552-005-0168-y

Cite this article as:
Dietrich, M., Block, G., Pogoda, J.M. et al. Cancer Causes Control (2005) 16: 619. doi:10.1007/s10552-005-0168-y

Abstract

Maternal dietary exposure to N-nitroso compounds (NOC) or to their precursors during pregnancy has been associated with risk of childhood brain tumors. Cured meat is one source of exposure to dietary NOC and their precursors. Most epidemiological studies that have examined the role of maternal consumption of cured meats during pregnancy have found a significant positive association between maternal intake of cured meat and the risk of childhood brain tumor (CBT). NOC consist of two main groups, N-nitrosamines and N-nitrosamides. The carcinogenicity profiles of NOC suggest that N-nitrosamides rather than N-nitrosamines are the compounds that may be associated with CBT and that they should be investigated more closely in epidemiological studies. We present a review of the chemical and carcinogenic properties of NOC in connection with the findings of case–control studies. This approach may be helpful in determining the essential information that must be collected in future epidemiological studies on CBT.

Keywords

dietN-nitroso compoundschildhood brain tumors

Abbreviations

NOC

N-nitroso compounds

NOx

nitrogen oxides

VNA

volatile N-nitrosamines

NVNA

non−volatile N-nitrosamines

NDMA

N-nitrosodimethylamine

NDEA

N-nitrosodiethylamine

NPYR

N-nitrosopyrrolidine

NPIP

N-nitrosopiperidine

MNU

Methylnitrosourea (N-nitroso-N-methyLurea)

ENU

Ethylnitrosourea (N-nitroso-N-ethyLurea)

NTHZ

N-nitrosothiazolidine

NHMTCA

N-nitroso-2-(hydroxymethyl)-thiazolidine-4-carboxylic acid

NTCA

N-nitrosothiazolidine-4-carboxylic acid

NTHZCA

N-nitrosothiazolidine-4-carboxylic acid and related homologues.

Copyright information

© Springer 2005

Authors and Affiliations

  • Marion Dietrich
    • 1
    • 4
  • Gladys Block
    • 1
  • Janice M. Pogoda
    • 2
  • Patricia Buffler
    • 1
  • Stephen Hecht
    • 3
  • Susan Preston -Martin
    • 2
  1. 1.School of Public HealthUniversity of CaliforniaBerkeleyUSA
  2. 2.Department of Preventive MedicineUniversity of Southern CaliforniaLos AngelesUSA
  3. 3.The Cancer CenterUniversity of MinnesotaMinneapolisUSA
  4. 4.Jean Mayer United States Department of AgricultureHuman Nutrition Research Center on Aging at Tufts UniversityBostonUSA