Cancer Causes & Control

, Volume 16, Issue 4, pp 389–397

Leisure-time physical activity and lung cancer: a meta-analysis

Authors

    • Division of Cancer Epidemiology and GeneticsNational Cancer Institute
    • Department of Public Health, Facultad de MedicinaUniversidad de Oviedo,
  • Won Jin Lee
    • Division of Cancer Epidemiology and GeneticsNational Cancer Institute
    • Department of Preventive Medicine, College of MedicineKorea University
  • Miguel Delgado-Rodriguez
    • Departamento de Medicina PreventivaUniversidad de Jaen
  • Mustafa Dosemeci
    • Division of Cancer Epidemiology and GeneticsNational Cancer Institute
  • Demetrius Albanes
    • Division of Cancer Epidemiology and GeneticsNational Cancer Institute
  • Robert Hoover
    • Division of Cancer Epidemiology and GeneticsNational Cancer Institute
  • Aaron Blair
    • Division of Cancer Epidemiology and GeneticsNational Cancer Institute
Article

DOI: 10.1007/s10552-004-5026-9

Cite this article as:
Tardon, A., Lee, W.J., Delgado-Rodriguez, M. et al. Cancer Causes Control (2005) 16: 389. doi:10.1007/s10552-004-5026-9

Abstract

Objective: Several studies have evaluated the relationship between physical activity and lung cancer. To summarize and review these studies, we conducted a meta-analysis of all relevant reports published from 1966 through October 2003.

Method: Adjusted odds ratios (ORs) from the original studies were pooled by the inverse of their variance, and all pooled estimates were accompanied by an assessment of heterogeneity across investigations. Test for linear trend across activity categories (low, moderate, high) were applied.

Results: The combined ORs were 0.87 (95 confidence interval=0.79–0.95) for moderate leisure-time physical activity (LPA) and 0.70 (0.62–0.79) for high activity (ptrend = 0.00). This inverse association occurred for both sexes, although it was somewhat stronger for women. No evidence of publication bias was found. Several studies were able to adjust for smoking, but none adjusted for possible confounding from previous malignant respiratory disease. Our simulations suggest that this condition is unlikely to entirely explain the inverse association.

Conclusion: The findings of this meta-analysis indicate that higher levels of LPA protect against lung cancer. The inverse association is possible remains confounded by inadequately controlled smoking patterns. However on the whole, confounding seems an unlikely explanation for the findings of individual studies on non-smokers.

Keywords

leisure physical activity lung cancer risk meta-analysis.

Copyright information

© Springer 2005