Cancer Causes & Control

, Volume 16, Issue 3, pp 263–273

Sexually transmitted diseases and other urogenital conditions as risk factors for prostate cancer: a case–control study in Wayne County, Michigan

  • Divya A. Patel
  • Cathryn H. Bock
  • Kendra Schwartz
  • Angela S. Wenzlaff
  • Raymond Y. Demers
  • Richard K. Severson
Article

DOI: 10.1007/s10552-004-3486-6

Cite this article as:
Patel, D.A., Bock, C.H., Schwartz, K. et al. Cancer Causes Control (2005) 16: 263. doi:10.1007/s10552-004-3486-6

Abstract

Objective To investigate associations between prostate cancer and sexually transmitted diseases (STDs), prostatitis, benign prostatic hyperplasia (BPH), and vasectomy in a population-based case–control study in Wayne County, Michigan, among African American and white men aged 50–74 years.

Methods: Incident prostate cancer cases (n=700) from 1996–1998 were identified from the Metropolitan Detroit Cancer Surveillance System. Controls (n=604) were identified through random digit dialing and Medicare recipient lists, and frequency matched to cases on age and race. History of potential prostate cancer risk factors was ascertained through in-person interview.

Results: Prostate cancer was not associated with STD or vasectomy history. History of prostatitis was associated with prostate cancer among all subjects (odds ratio [OR]=1.8, 95% confidence interval [CI]: 1.1, 2.9) and in African American men (OR=2.2, 95% CI: 1.1, 4.6). History of BPH was associated with prostate cancer among all subjects (OR=2.4, 95% CI: 1.8, 3.3); significant associations were observed in both African American (OR=2.7, 95% CI: 1.6, 4.4) and white (OR=2.3, 95% CI: 1.5, 3.4) men.

Conclusions: Among all subjects, prostate cancer was associated with prostatitis and BPH history, but not with STD or vasectomy history. Prevention efforts could be enhanced if inflammatory or infectious etiologies are found to be of importance in the subsequent development of prostate cancer.

Keywords

benign prostatic hyperplasiaprostatic neoplasmsprostatitisSEER programsexually transmitted diseasesvasectomy

Copyright information

© Springer 2005

Authors and Affiliations

  • Divya A. Patel
    • 1
    • 4
  • Cathryn H. Bock
    • 1
  • Kendra Schwartz
    • 2
  • Angela S. Wenzlaff
    • 1
  • Raymond Y. Demers
    • 3
  • Richard K. Severson
    • 2
  1. 1.Karmanos Cancer InstituteWayne State UniversityDetroitUSA
  2. 2.Karmanos Cancer Institute and Department of Family MedicineWayne State UniversityDetroitUSA
  3. 3.Great Lakes Cancer Institute and Department of Internal MedicineMichigan State UniversityEast LansingUSA
  4. 4.Department of Obstetrics and GynecologyUniversity of MichiganAnn ArborUSA