Cancer Causes & Control

, Volume 15, Issue 9, pp 853–862

Dietary patterns and risk of colon cancer and adenoma in a cohort of men (United States)

Authors

    • Department of NutritionHarvard School of Public Health
  • Frank B. Hu
    • Department of NutritionHarvard School of Public Health
    • Department of EpidemiologyHarvard School of Public Health
  • Charles Fuchs
    • Channing Laboratory, Department of MedicineBrigham and Women’s Hospital, Harvard Medical School
    • Division of Medical OncologyDana-Farber Cancer Institute
  • Eric B. Rimm
    • Department of NutritionHarvard School of Public Health
    • Channing Laboratory, Department of MedicineBrigham and Women’s Hospital, Harvard Medical School
    • Department of EpidemiologyHarvard School of Public Health
  • Walter C. Willett
    • Department of NutritionHarvard School of Public Health
    • Channing Laboratory, Department of MedicineBrigham and Women’s Hospital, Harvard Medical School
    • Department of EpidemiologyHarvard School of Public Health
  • Edward Giovannucci
    • Department of NutritionHarvard School of Public Health
    • Channing Laboratory, Department of MedicineBrigham and Women’s Hospital, Harvard Medical School
    • Department of EpidemiologyHarvard School of Public Health
Article

DOI: 10.1007/s10552-004-1809-2

Cite this article as:
Wu, K., Hu, F.B., Fuchs, C. et al. Cancer Causes Control (2004) 15: 853. doi:10.1007/s10552-004-1809-2

Abstract

BackgroundExamining the effects of dietary patterns on cancer risk may provide insights beyond the assessment of individual foods or nutrients. Design: In the health professionals follow-up cohort, associations between the ‘prudent’ and the ‘western’ dietary pattern and risk of colon cancer and adenomas were examined in 561 colon cancer cases and 1207 distal colon adenoma cases. Results: Higher prudent pattern scores were only weakly and non-significantly associated with decreased risk of colon cancer or distal colon adenoma (highest versus lowest quintile: colon cancer: multivariate adjusted relative risk (RR)=0.84 (95 confidence interval (CI)=0.64–1.10); ptrend=0.37; distal adenoma: multivariate odds ratio (OR)=0.88 (95 CI=0.73–1.08); ptrend=0.12). Our findings suggest a moderately increased risk of colon cancer and distal adenoma with higher western pattern scores (colon cancer: RR=1.27 (95 CI=0.96–1.69), ptrend=0.05; distal adenoma: OR=1.28 (95 CI=1.05–1.56), ptrend=0.01). Adding body mass index, which is positively related to western pattern and thus may be considered an intermediate endpoint between western pattern and colon cancer, attenuated associations somewhat but not substantially. Conclusion: Our data do not provide evidence for an appreciable inverse association between higher prudent pattern scores and risk of colon cancer or distal colon adenomas, but do support a moderate positive association between higher western pattern scores and risk of colon cancer or distal colon adenomas.

Keywords

colon adenomacolon cancerdietary patternmen

Copyright information

© Kluwer Academic Publishers 2004