Breast Cancer Research and Treatment

, Volume 149, Issue 1, pp 263–268

No effect of scalp cooling on survival among women with breast cancer

  • J. Lemieux
  • L. Provencher
  • L. Perron
  • J. Brisson
  • C. Amireault
  • C. Blanchette
  • E. Maunsell
Epidemiology

DOI: 10.1007/s10549-014-3231-0

Cite this article as:
Lemieux, J., Provencher, L., Perron, L. et al. Breast Cancer Res Treat (2015) 149: 263. doi:10.1007/s10549-014-3231-0

Abstract

Scalp cooling can prevent chemotherapy-induced alopecia in some cancer patients. It is not used in all countries. No data are available regarding its impact, if any, on survival. The aim of this study was to compare overall survival according to whether or not scalp cooling was used during neoadjuvant or adjuvant chemotherapy for non-metastatic breast cancer. We conducted a retrospective cohort study of 1,370 women with non-metastatic invasive breast carcinoma who received chemotherapy in the neoadjuvant or adjuvant setting. A total of 553 women who used scalp cooling came from a tertiary breast cancer clinic in Quebec City (diagnosed between 1998 and 2002) and 817 were treated in other hospitals in the province of Quebec (between 1998 and 2003) where scalp cooling was not routinely available. Overall survival of women who used scalp cooling and those who did not was compared using Cox proportional hazards models. Median follow-up for the scalp-cooled and the non-scalp-cooled groups was 6.3 years and 8.0 years, respectively. Overall mortality was no different (adjusted hazard ratio 0.89, 95 % confidence interval: 0.68–1.17, p = 0.40) among scalp-cooled women, compared to those not getting scalp cooling. Among women getting neoadjuvant or adjuvant chemotherapy for non-metastatic breast cancer, scalp cooling used to prevent chemotherapy-induced alopecia had no negative effect on survival. To our knowledge, this is the first study to compare survival of women who used scalp cooling to that of women who did not.

Keywords

Breast cancer Scalp cooling Survival Alopecia 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • J. Lemieux
    • 1
    • 2
    • 3
  • L. Provencher
    • 1
    • 2
    • 4
  • L. Perron
    • 5
    • 6
  • J. Brisson
    • 1
    • 2
    • 5
    • 6
  • C. Amireault
    • 7
  • C. Blanchette
    • 1
    • 2
  • E. Maunsell
    • 1
    • 2
    • 5
  1. 1.Centre de rechercheCentre hospitalier universitaire (CHU) de Québec, Hôpital du Saint-SacrementQuébecCanada
  2. 2.Centre des Maladies du Sein Deschênes-FabiaCentre hospitalier universitaire (CHU) de Québec-Hôpital du St-SacrementQuebecCanada
  3. 3.Département de médecine, Faculté de MédecineUniversité Laval, Pavillon Ferdinand-VandryQuebecCanada
  4. 4.Département de chirurgie, Faculté de MédecineUniversité Laval, Pavillon Ferdinand-VandryQuebecCanada
  5. 5.Département de médecine sociale et préventive, Faculté de MédecineUniversité Laval, Pavillon Ferdinand-VandryQuebecCanada
  6. 6.Institut Nationale de Santé PubliqueQuebecCanada
  7. 7.Faculté de MédecineUniversité Laval, Pavillon Ferdinand-VandryQuebecCanada

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