Breast Cancer Research and Treatment

, Volume 142, Issue 1, pp 119–132

Favorable modulation of benign breast tissue and serum risk biomarkers is associated with >10 % weight loss in postmenopausal women

Authors

    • Department of Internal MedicineUniversity of Kansas Medical Center
  • Bruce F. Kimler
    • Department of Radiation OncologyUniversity of Kansas Medical Center
  • Joseph E. Donnelly
    • Department of Internal MedicineUniversity of Kansas Medical Center
  • Debra K. Sullivan
    • Department of Dietetics and NutritionUniversity of Kansas Medical Center
  • Jennifer R. Klemp
    • Department of Internal MedicineUniversity of Kansas Medical Center
  • Brian K. Petroff
    • Department of Internal MedicineUniversity of Kansas Medical Center
  • Teresa A. Phillips
    • Department of Internal MedicineUniversity of Kansas Medical Center
  • Trina Metheny
    • Department of Internal MedicineUniversity of Kansas Medical Center
  • Sonya Aversman
    • Department of Internal MedicineUniversity of Kansas Medical Center
  • Hung-wen Yeh
    • Department of BiostatisticsUniversity of Kansas Medical Center
  • Carola M. Zalles
    • Mercy Hospital
  • Gordon B. Mills
    • Department of Systems BiologyUniversity of Texas MD Anderson Cancer Center
  • Stephen D. Hursting
    • Department of Nutritional SciencesUniversity of Texas at Austin
Clinical trial

DOI: 10.1007/s10549-013-2730-8

Cite this article as:
Fabian, C.J., Kimler, B.F., Donnelly, J.E. et al. Breast Cancer Res Treat (2013) 142: 119. doi:10.1007/s10549-013-2730-8

Abstract

We conducted a phase II feasibility study of a 6-month behavioral weight loss intervention in postmenopausal overweight and obese women at increased risk for breast cancer and the effects of weight loss on anthropomorphic, blood, and benign breast tissue biomarkers. 67 women were screened by random peri-areolar fine-needle aspiration, 27 were registered and 24 participated in the interventional phase. The 24 biomarker evaluable women had a median baseline BMI of 34.2 kg/m2 and lost a median of 11 % of their initial weight. Significant tissue biomarker modulation after the 6-month intervention was noted for Ki-67 (if restricted to the 15 women with any Ki-67 at baseline, p = 0.041), adiponectin to leptin ratio (p = 0.003); and cyclin B1 (p = 0.001), phosphorylated retinoblastoma (p = 0.005), and ribosomal S6 (p = 0.004) proteins. Favorable modulation for serum markers was observed for sex hormone-binding globulin (p < 0.001), bioavailable estradiol (p < 0.001), bioavailable testosterone (p = 0.033), insulin (p = 0.018), adiponectin (p = 0.001), leptin (p < 0.001), the adiponectin to leptin ratio (p < 0.001), C-reactive protein (p = 0.002), and hepatocyte growth factor (p = 0.011). When subdivided by <10 or >10 % weight loss, change in percent total body and android (visceral) fat, physical activity, and the majority of the serum and tissue biomarkers were significantly modulated only for women with >10 % weight loss from baseline. Some factors such as serum PAI-1 and breast tissue pS2 (estrogen-inducible gene) mRNA were not significantly modulated overall but were when considering only those with >10 % weight loss. In conclusion, a median weight loss of 11 % over 6 months resulted in favorable modulation of a number of anthropomorphic, breast tissue and serum risk and mechanistic markers. Weight loss of 10 % or more should likely be the goal for breast cancer risk reduction studies in obese women.

Keywords

Breast risk biomarkers with weight lossRPFNAEnergy balance

Supplementary material

10549_2013_2730_MOESM1_ESM.pdf (90 kb)
Supplementary material 1 (PDF 90 kb)
10549_2013_2730_MOESM2_ESM.pdf (20 kb)
Supplementary material 2 (PDF 20 kb)
10549_2013_2730_MOESM3_ESM.pdf (54 kb)
Supplementary material 3 (PDF 55 kb)
10549_2013_2730_MOESM4_ESM.pdf (69 kb)
Supplementary material 4 (PDF 70 kb)

Copyright information

© Springer Science+Business Media New York 2013