Review

Breast Cancer Research and Treatment

, Volume 141, Issue 1, pp 1-12

Paget’s disease of the nipple

  • Ana C. Sandoval-LeonAffiliated withDepartment of Medicine, Division of Hematology/Oncology, University of Miami Miller School of Medicine
  • , Katherine Drews-ElgerAffiliated withDepartment of Medicine, Division of Hematology/Oncology, University of Miami Miller School of Medicine Email author 
  • , Carmen R. Gomez-FernandezAffiliated withDepartment of Pathology, University of Miami Miller School of Medicine
  • , Monica M. YepesAffiliated withDepartment of Radiology, University of Miami Miller School of Medicine
  • , Marc E. LippmanAffiliated withDepartment of Medicine, Division of Hematology/Oncology, University of Miami Miller School of Medicine

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Abstract

Paget’s disease of the breast is a disorder of the nipple–areola complex that, while rare, is often associated with an underlying carcinoma. It is characterized by eczematoid changes of the nipple. Two theories have been proposed to explain the pathogenesis of Paget’s disease. The Epidermotropic, which is the most accepted theory, suggests that Paget’s cells originate from ductal cancer cells that had migrated from the underlying breast parenchyma. It is supported by the predominance of breast cancer markers found in Paget’s disease. This article provides an overview of Paget’s disease of the breast with special attention to immunohistochemistry and raises the question of new therapeutic approaches.

Keywords

Paget’s disease Breast cancer Her2 Immunohistochemistry