Breast Cancer Research and Treatment

, Volume 138, Issue 2, pp 331–346

Diagnostic and prognostic application of positron emission tomography in breast imaging: emerging uses and the role of PET in monitoring treatment response

  • Jessica Anna Cintolo
  • Julia Tchou
  • Daniel A. Pryma
Review

DOI: 10.1007/s10549-013-2451-z

Cite this article as:
Cintolo, J.A., Tchou, J. & Pryma, D.A. Breast Cancer Res Treat (2013) 138: 331. doi:10.1007/s10549-013-2451-z

Abstract

Positron emission tomography (PET) is an imaging modality that using radiotracers, permits real-time dynamic monitoring of biologic processes such as cell metabolic behavior and proliferation, and has proven useful as a research tool for understanding tumor biology. While it does not have a well-defined role in breast cancer for the purposes of screening, diagnosis, or prognosis, emerging PET technologies and uses could expand the applications of PET in breast cancer. Positron emission mammography may provide an alternative adjunct imaging modality for the screening and diagnosis of high-risk patients unable to tolerate MRI. The development of radiotracers with the ability to measure hormonal activity could provide a non-invasive way to assess hormone receptor status and functionality. Finally, the role of PET technologies in monitoring early treatment response may prove particularly useful to research involving new therapeutic interventions.

Keywords

Breast cancerPETFDG PETFLT-PETFES-PETPET/CTEarly treatment response

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Jessica Anna Cintolo
    • 1
  • Julia Tchou
    • 1
  • Daniel A. Pryma
    • 2
  1. 1.Department of SurgeryHospital of the University of PennsylvaniaPhiladelphiaUSA
  2. 2.Department of RadiologyHospital of the University of PennsylvaniaPhiladelphiaUSA