, Volume 133, Issue 2, pp 805-807
Date: 14 Mar 2012

The SNP rs895819 in miR-27a is not associated with familial breast cancer risk in Italians

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To the Editor,

MicroRNAs (miRNAs) are a class of small non-coding RNA implicated in gene expression; deregulation of miRNAs, accounted by somatic variations, may lead to initiation and progression of several types of cancers [1]. It has been postulated that also common germline variants located within miRNA genes may be associated with cancer risk. In particular, the single nucleotide polymorphisms (SNPs) rs2910164, rs11614913, rs3746444, and rs6505162 located within miR-146a, miR-196a2, miR-499, and miR-423, respectively, resulted all associated with breast cancer risk [2, 3]. However, a subsequent large study on SNPs in miR-146a, miR-192a2, and miR-499 did not replicate these findings [4]. Two following meta-analyses confirmed the association for the SNP in miR-196a2 and the lack of association for the SNP in miR-146a [5, 6]. The rare allele of the rs12975333 in miRNA-125a was found strongly associated with breast cancer risk in Antwerp, Belgium [7], but a multicenter study reported n ...