Breast Cancer Research and Treatment

, Volume 127, Issue 3, pp 813–818

Current evidence on the relationship between four polymorphisms in the matrix metalloproteinases (MMP) gene and breast cancer risk: a meta-analysis

  • Ping Zhou
  • Liang-Feng Du
  • Guo-Qiang Lv
  • Xian-Ming Yu
  • Yuan-Long Gu
  • Jian-Ping Li
  • Chun Zhang
Epidemiology

DOI: 10.1007/s10549-010-1294-0

Cite this article as:
Zhou, P., Du, LF., Lv, GQ. et al. Breast Cancer Res Treat (2011) 127: 813. doi:10.1007/s10549-010-1294-0

Abstract

The matrix metalloproteinases (MMP) can degrade various components of the extracellular matrix and its functional genetic polymorphisms may be associated with breast cancer risk. However, this relationship remains controversial. A meta-analysis was conducted in order to investigate the potential association between four polymorphisms in the MMP gene and breast cancer risk. A database search yielded a total of 9 studies involving 2,597 cases and 2,618 controls. Four polymorphisms were included in the meta-analysis: MMP-1 −1607 2G/1G (rs1799750), MMP-2 −1306 C/T (rs243865), MMP-3 −1171 6A/5A (rs3025058) and MMP-9 −1562 C/T (rs3918242). Crude odds ratios (OR) with 95% confidence intervals (CI) were used to assess the strength of association. When all the studies were pooled into the meta-analysis, we found that breast cancer cases had a significantly higher frequency of CC genotype (OR = 1.27, 95% CI = 1.10, 1.47; P = 0.001) and lower frequency of CT genotype (OR = 0.78, 95% CI = 0.67, 0.91; P = 0.001) of MMP-2. No significant difference was found in any genotype of MMP-1, MMP-3 or MMP-9. In conclusion, this meta-analysis suggested that MMP-2 −1306 C/T polymorphism may contribute to breast cancer susceptibility. More studies were needed especially in Asians in the future.

Keywords

Matrix metalloproteinasesBreast cancerPolymorphismMeta-analysis

Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  • Ping Zhou
    • 1
    • 2
  • Liang-Feng Du
    • 1
  • Guo-Qiang Lv
    • 2
  • Xian-Ming Yu
    • 2
  • Yuan-Long Gu
    • 2
  • Jian-Ping Li
    • 2
  • Chun Zhang
    • 2
  1. 1.Department of Intensive Care UniteThe Third Affiliated Hospital to Nantong UniversityWuxiChina
  2. 2.Department of General SurgeryThe Third Affiliated Hospital to Nantong UniversityWuxiChina