Breast Cancer Research and Treatment

, Volume 125, Issue 2, pp 571–574

The association between two polymorphisms in pre-miRNAs and breast cancer risk: a meta-analysis

  • Lin-Bo Gao
  • Peng Bai
  • Xin-Min Pan
  • Jing Jia
  • Li-Juan Li
  • Wei-Bo Liang
  • Ming Tang
  • Lu-Shun Zhang
  • Yong-Gang Wei
  • Lin Zhang
Epidemiology

DOI: 10.1007/s10549-010-0993-x

Cite this article as:
Gao, L., Bai, P., Pan, X. et al. Breast Cancer Res Treat (2011) 125: 571. doi:10.1007/s10549-010-0993-x

Abstract

Emerging evidence has shown that miRNAs participate in human carcinogenesis as tumor suppressors or oncogenes. Single nucleotide polymorphism (SNP) which located in the pre-miRNA may affect the processing and then influence the expression of mature miRNA. Previous studies yielded conflicting results as to the association of two common polymorphisms in pre-miRNAs (i.e. hsa-miR-146 rs2910164 and hsa-miR-196a2 rs11614913) with breast cancer. To derive a more precise effect on the association between these polymorphisms and breast cancer risk, we conducted a meta-analysis. Through retrieving PubMed for the period up to May 2010, a total of four studies were identified with 3,007 cases and 3,718 controls for has-miR-146a rs2910164 polymorphism and with 3,287 cases and 4,298 controls for hsa-miR-196a2 rs11614913 polymorphism. We found that individuals carrying CC genotype of has-miR-196a2 rs11614913 polymorphism was associated with an increased breast cancer risk in homozygote comparison (OR = 1.30; 95% CI, 1.01-1.68), and dominant model (OR = 1.11; 95% CI, 1.01-1.23). However, no significant association between has-miR-146a rs2910164 polymorphism and breast cancer risk was observed in all comparison models tested. These findings suggest that has-miR-196a2 rs11614913 polymorphism may play crucial roles in breast cancer development.

Keywords

Hsa-miR-146 rs2910164Has-miR-196a2 rs11614913Single nucleotide polymorphismBreast cancerMeta-analysis

Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  • Lin-Bo Gao
    • 1
  • Peng Bai
    • 2
  • Xin-Min Pan
    • 2
    • 3
  • Jing Jia
    • 4
  • Li-Juan Li
    • 2
  • Wei-Bo Liang
    • 2
  • Ming Tang
    • 5
  • Lu-Shun Zhang
    • 2
  • Yong-Gang Wei
    • 6
  • Lin Zhang
    • 1
  1. 1.Laboratory of Molecular Translational Medicine, West China Second University HospitalSichuan UniversityChengduP.R.China
  2. 2.Department of Forensic Biology, West China School of Preclinical and Forensic MedicineSichuan UniversityChengduP.R.China
  3. 3.Department of Forensic PathologyHenan University of Science and TechnologyLuoyangP.R.China
  4. 4.Department of Normal PharmacologyZhejiang Academy of Medical Sciences (ZAMS)HangzhouP.R.China
  5. 5.Department of PathologyThe First People’s Hospital of Yunnan ProvinceKunmingP.R.China
  6. 6.Department of General SurgeryWest China Hospital of Sichuan UniversityChengduP.R.China