Breast Cancer Research and Treatment

, Volume 125, Issue 2, pp 571–574

The association between two polymorphisms in pre-miRNAs and breast cancer risk: a meta-analysis

Authors

  • Lin-Bo Gao
    • Laboratory of Molecular Translational Medicine, West China Second University HospitalSichuan University
  • Peng Bai
    • Department of Forensic Biology, West China School of Preclinical and Forensic MedicineSichuan University
  • Xin-Min Pan
    • Department of Forensic Biology, West China School of Preclinical and Forensic MedicineSichuan University
    • Department of Forensic PathologyHenan University of Science and Technology
  • Jing Jia
    • Department of Normal PharmacologyZhejiang Academy of Medical Sciences (ZAMS)
  • Li-Juan Li
    • Department of Forensic Biology, West China School of Preclinical and Forensic MedicineSichuan University
  • Wei-Bo Liang
    • Department of Forensic Biology, West China School of Preclinical and Forensic MedicineSichuan University
  • Ming Tang
    • Department of PathologyThe First People’s Hospital of Yunnan Province
  • Lu-Shun Zhang
    • Department of Forensic Biology, West China School of Preclinical and Forensic MedicineSichuan University
  • Yong-Gang Wei
    • Department of General SurgeryWest China Hospital of Sichuan University
    • Laboratory of Molecular Translational Medicine, West China Second University HospitalSichuan University
Epidemiology

DOI: 10.1007/s10549-010-0993-x

Cite this article as:
Gao, L., Bai, P., Pan, X. et al. Breast Cancer Res Treat (2011) 125: 571. doi:10.1007/s10549-010-0993-x

Abstract

Emerging evidence has shown that miRNAs participate in human carcinogenesis as tumor suppressors or oncogenes. Single nucleotide polymorphism (SNP) which located in the pre-miRNA may affect the processing and then influence the expression of mature miRNA. Previous studies yielded conflicting results as to the association of two common polymorphisms in pre-miRNAs (i.e. hsa-miR-146 rs2910164 and hsa-miR-196a2 rs11614913) with breast cancer. To derive a more precise effect on the association between these polymorphisms and breast cancer risk, we conducted a meta-analysis. Through retrieving PubMed for the period up to May 2010, a total of four studies were identified with 3,007 cases and 3,718 controls for has-miR-146a rs2910164 polymorphism and with 3,287 cases and 4,298 controls for hsa-miR-196a2 rs11614913 polymorphism. We found that individuals carrying CC genotype of has-miR-196a2 rs11614913 polymorphism was associated with an increased breast cancer risk in homozygote comparison (OR = 1.30; 95% CI, 1.01-1.68), and dominant model (OR = 1.11; 95% CI, 1.01-1.23). However, no significant association between has-miR-146a rs2910164 polymorphism and breast cancer risk was observed in all comparison models tested. These findings suggest that has-miR-196a2 rs11614913 polymorphism may play crucial roles in breast cancer development.

Keywords

Hsa-miR-146 rs2910164 Has-miR-196a2 rs11614913 Single nucleotide polymorphism Breast cancer Meta-analysis

Copyright information

© Springer Science+Business Media, LLC. 2010