Breast Cancer Research and Treatment

, Volume 122, Issue 3, pp 637–645

Papillary carcinoma of the breast: an overview

  • Sumanta Kumar Pal
  • Sean K. Lau
  • Laura Kruper
  • Uzoamaka Nwoye
  • Carlos Garberoglio
  • Ravi K. Gupta
  • Benjamin Paz
  • Lalit Vora
  • Eduardo Guzman
  • Avo Artinyan
  • George Somlo
Review

DOI: 10.1007/s10549-010-0961-5

Cite this article as:
Pal, S.K., Lau, S.K., Kruper, L. et al. Breast Cancer Res Treat (2010) 122: 637. doi:10.1007/s10549-010-0961-5

Abstract

Papillary carcinoma of the breast represents ~0.5% of all newly diagnosed cases of breast cancer. The prevalence of both invasive and in situ papillary carcinoma seems to be greater in older postmenopausal women and, in relative terms, in males. Histologic features of the tumor include cellular proliferations surrounding fibrovascular cores, with or without invasion. In this review, characteristics of both in situ and invasive disease are outlined. Immunohistochemical analyses of papillary carcinoma suggest the utility of markers such as smooth muscle myosin heavy chain, calponin, p63, and high molecular weight keratins, which can characterize the myoepithelial cell layer. With respect to radiographic evaluation of papillary carcinoma, ultrasonography is the most extensively studied imaging modality, though magnetic resonance mammography has potential utility. Available data suggest improved outcome for papillary carcinoma as compared to invasive ductal carcinoma. Treatment-related information for patients with papillary carcinoma is limited, and patterns noted in available series suggest a variable approach to this disease. The scarcity of information underscores the need for further treatment- and outcome-related studies in papillary carcinoma of the breast.

Keywords

PapillaryBreast carcinomaMale breast cancerBreast ultrasonographyBreast magnetic resonance mammography

Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  • Sumanta Kumar Pal
    • 1
  • Sean K. Lau
    • 2
  • Laura Kruper
    • 3
  • Uzoamaka Nwoye
    • 3
  • Carlos Garberoglio
    • 4
  • Ravi K. Gupta
    • 1
  • Benjamin Paz
    • 3
  • Lalit Vora
    • 5
  • Eduardo Guzman
    • 3
  • Avo Artinyan
    • 3
  • George Somlo
    • 1
  1. 1.Department of Medical Oncology & Therapeutics ResearchCity of Hope Comprehensive Cancer CenterDuarteUSA
  2. 2.Department of PathologyCity of Hope Comprehensive Cancer CenterDuarteUSA
  3. 3.Department of General Oncologic SurgeryCity of Hope Comprehensive Cancer CenterDuarteUSA
  4. 4.Department of SurgeryLoma Linda University HospitalLoma LindaUSA
  5. 5.Department of RadiologyCity of Hope Comprehensive Cancer CenterDuarteUSA