Breast Cancer Research and Treatment

, Volume 125, Issue 1, pp 157–161

RAD51 G135C polymorphism is associated with breast cancer susceptibility: a meta-analysis involving 22,399 subjects

  • Haiming Sun
  • Jing Bai
  • Feng Chen
  • Yan Jin
  • Yang Yu
  • Lianhong Jin
  • Songbin Fu
Epidemiology

DOI: 10.1007/s10549-010-0922-z

Cite this article as:
Sun, H., Bai, J., Chen, F. et al. Breast Cancer Res Treat (2011) 125: 157. doi:10.1007/s10549-010-0922-z

Abstract

Several studies have investigated the associations between RAD51 G135C polymorphism and the susceptibility to breast cancer, but results have been inconclusive. In order to derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 17 case control studies, including 12,153 cases and 10,245 controls, were selected. Overall, significant decreased risk was found for the additive model (OR = 0.995, 95% CI = 0.991–0.998) and dominant model (OR = 0.994, 95% CI = 0.991–0.998). In the subgroup analysis by ethnicity, statistically significantly decreased risk was found in Asians (additive model: OR = 0.977, 95% CI = 0.954–1.000 and dominant model: OR = 0.981, 95% CI = 0.963–1.000). In conclusion, this meta-analysis suggests that the RAD51 G135C polymorphism is a low-penetrant risk factor for developing breast cancer.

Keywords

RAD51 Polymorphism Breast cancer Meta-analysis 

Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  • Haiming Sun
    • 1
  • Jing Bai
    • 1
  • Feng Chen
    • 1
  • Yan Jin
    • 1
    • 2
  • Yang Yu
    • 1
  • Lianhong Jin
    • 3
  • Songbin Fu
    • 1
  1. 1.Laboratory of Medical GeneticsHarbin Medical UniversityHarbinChina
  2. 2.Key Laboratory of Medical Genetics (Harbin Medical University), Heilongjiang Higher Education InstitutionsHarbinChina
  3. 3.Department of Histology and EmbryologyHarbin Medical UniversityHarbinChina