Breast Cancer Research and Treatment

, Volume 124, Issue 2, pp 487–495

Change in lifestyle behaviors and medication use after a diagnosis of ductal carcinoma in situ

  • Brian L. Sprague
  • Amy Trentham-Dietz
  • Hazel B. Nichols
  • John M. Hampton
  • Polly A. Newcomb
Epidemiology

DOI: 10.1007/s10549-010-0869-0

Cite this article as:
Sprague, B.L., Trentham-Dietz, A., Nichols, H.B. et al. Breast Cancer Res Treat (2010) 124: 487. doi:10.1007/s10549-010-0869-0

Abstract

Women with ductal carcinoma in situ (DCIS) of the breast represent a growing cancer survivor population with a diagnosis of uncertain malignant potential. These survivors face an absence of scientific guidelines regarding lifestyle changes that can help to prevent a breast cancer recurrence. In this first report from the Wisconsin In Situ Cohort (WISC) study, we examine how women are currently changing their lifestyle behaviors and medication use following a diagnosis of DCIS. At study entry (1997–2006), 1,959 subjects (78% of eligible) with DCIS were identified from the Wisconsin cancer registry and administered an interview assessing behaviors prior to diagnosis. Follow-up interviews were completed every 2 years after the initial interview, beginning in 2003 and continuing through 2006. After adjusting for age and calendar year, women were 2.2 kg (95% CI 1.4, 3.0) heavier, 35% (95% CI 20, 47) less likely to be a smoker, 19% (95% CI −1, 43) more likely to use non-steroidal anti-inflammatory drugs, and 57% (95% CI 26, 95) more likely to use antidepressants after a DCIS diagnosis compared to 1 year prior to diagnosis. Use of postmenopausal hormones decreased sharply (OR = 0.06; 95% CI 0.04, 0.09) following a DCIS diagnosis. These findings indicate that women make substantial changes in their behaviors after a DCIS diagnosis. This cohort will be further monitored to evaluate the association between these behaviors and health outcomes following DCIS.

Keywords

Breast neoplasmsDuctal carcinoma in situEpidemiologyCohort studyHealth behaviors

Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  • Brian L. Sprague
    • 1
    • 2
  • Amy Trentham-Dietz
    • 1
    • 2
  • Hazel B. Nichols
    • 2
  • John M. Hampton
    • 2
  • Polly A. Newcomb
    • 2
    • 3
  1. 1.Department of Population Health SciencesUniversity of Wisconsin-MadisonMadisonUSA
  2. 2.University of Wisconsin Carbone Comprehensive Cancer CenterMadisonUSA
  3. 3.Cancer Prevention ProgramFred Hutchinson Cancer Research CenterSeattleUSA