Breast Cancer Research and Treatment

, Volume 124, Issue 2, pp 419–424

Current evidence on the relationship between three polymorphisms in the FGFR2 gene and breast cancer risk: a meta-analysis

  • Jian Zhang
  • Li-Xin Qiu
  • Zhong-Hua Wang
  • Shiang-Jiin Leaw
  • Bi-Yun Wang
  • Jia-Lei Wang
  • Zhi-Gang Cao
  • Jia-Li Gao
  • Xi-Chun Hu
Epidemiology

DOI: 10.1007/s10549-010-0846-7

Cite this article as:
Zhang, J., Qiu, LX., Wang, ZH. et al. Breast Cancer Res Treat (2010) 124: 419. doi:10.1007/s10549-010-0846-7
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Abstract

In this article, inconsistency of the association of polymorphisms of fibroblast growth factor receptor 2 (FGFR2) with breast cancer is noted. Three commonly studied FGFR2 polymorphisms including rs1219648 (A > G), rs2420946 (C > T), and rs2981582 (C > T) were selected to explore their association with risk of development of breast cancer by meta-analysis of published case–control studies. The results showed that all these three polymorphisms were significantly associated with altered breast cancer risk in any model (co-dominant, dominant, or recessive model) and in stratification based on ethnicity and study design. In the subgroup analyses for postmenopausal women, significantly increased risks were found for rs1219648 and rs2420946 in any model. This meta-analysis suggests that FGFR2 is likely an important genetic marker contributing to susceptibility of breast cancer. We recommend that these single nucleotide polymorphisms to be included in future association studies and functional assays.

Keywords

Fibroblast growth factor receptor 2 (FGFR2) Polymorphism Breast cancer Susceptibility Meta-analysis 

Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  • Jian Zhang
    • 1
    • 2
  • Li-Xin Qiu
    • 1
    • 2
  • Zhong-Hua Wang
    • 1
    • 2
  • Shiang-Jiin Leaw
    • 1
    • 2
  • Bi-Yun Wang
    • 1
    • 2
  • Jia-Lei Wang
    • 1
    • 2
  • Zhi-Gang Cao
    • 3
  • Jia-Li Gao
    • 4
  • Xi-Chun Hu
    • 1
    • 2
  1. 1.Department of Medical Oncology, Cancer Hospital Fudan UniversityShanghaiChina
  2. 2.Department of Oncology, Shanghai Medical College Fudan UniversityShanghaiChina
  3. 3.Department of Science and Education, Cancer Hospital Fudan UniversityShanghaiChina
  4. 4.The Engineering Training CenterChongqing University of TechnologyChongqingChina

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