Breast Cancer Research and Treatment

, Volume 125, Issue 1, pp 65–72

Presence of Foxp3 expression in tumor cells predicts better survival in HER2-overexpressing breast cancer patients treated with neoadjuvant chemotherapy

Authors

  • Sylvain Ladoire
    • Department of Medical OncologyCentre Regional de Lutte Contre le Cancer Georges François Leclerc
    • Institut National de la Santé et de la Recherche MédicaleUniversity of Dijon
    • Department of Pathology and Molecular BiologyCentre Regional de Lutte Contre le Cancer Georges François Leclerc
  • Laurent Arnould
    • Department of Pathology and Molecular BiologyCentre Regional de Lutte Contre le Cancer Georges François Leclerc
  • Grégoire Mignot
    • Institut National de la Santé et de la Recherche MédicaleUniversity of Dijon
  • Bruno Coudert
    • Department of Medical OncologyCentre Regional de Lutte Contre le Cancer Georges François Leclerc
  • Cédric Rébé
    • Institut National de la Santé et de la Recherche MédicaleUniversity of Dijon
    • Department of Pathology and Molecular BiologyCentre Regional de Lutte Contre le Cancer Georges François Leclerc
  • Fanny Chalmin
    • Institut National de la Santé et de la Recherche MédicaleUniversity of Dijon
  • Julie Vincent
    • Institut National de la Santé et de la Recherche MédicaleUniversity of Dijon
  • Mélanie Bruchard
    • Institut National de la Santé et de la Recherche MédicaleUniversity of Dijon
  • Bruno Chauffert
    • Department of Medical OncologyCentre Regional de Lutte Contre le Cancer Georges François Leclerc
    • Institut National de la Santé et de la Recherche MédicaleUniversity of Dijon
  • François Martin
    • Institut National de la Santé et de la Recherche MédicaleUniversity of Dijon
  • Pierre Fumoleau
    • Department of Medical OncologyCentre Regional de Lutte Contre le Cancer Georges François Leclerc
    • Department of Medical OncologyCentre Regional de Lutte Contre le Cancer Georges François Leclerc
    • Institut National de la Santé et de la Recherche MédicaleUniversity of Dijon
    • Department of Pathology and Molecular BiologyCentre Regional de Lutte Contre le Cancer Georges François Leclerc
    • Faculté de MédecineCentre Georges François Leclerc, Centre de Recherche INSERM 866
Preclinical study

DOI: 10.1007/s10549-010-0831-1

Cite this article as:
Ladoire, S., Arnould, L., Mignot, G. et al. Breast Cancer Res Treat (2011) 125: 65. doi:10.1007/s10549-010-0831-1

Abstract

The Forkhead Box Protein 3 is highly expressed not only in regulatory T cells, but also in tumor cells, acting as a transcriptional repressor of breast oncogenes including HER2. We investigated the prognostic significance of Foxp3 expression in cancer cells in a large cohort of patients with HER2-overexpressing breast carcinoma treated with neoadjuvant chemotherapy. Foxp3-positive tumor cells were detected by immunohistochemistry in 103 patients with primary invasive HER2-overexpressing breast carcinoma, and treated with neoadjuvant chemotherapy, with or without trastuzumab. Kaplan–Meier analysis and Cox regression model were used to assess relapse-free and overall survival, respectively, and according to the presence or the absence of Foxp3 expression in tumor cells. Breast cancer cells were Foxp3+ in 57% of tumors. Foxp3 expression in breast cancer cells was associated with better relapse-free (P = 0.005) and overall survival (P = 0.03). By multivariate analysis, the presence of Foxp3+ tumor cells produced an independent prognostic factor for both better relapse-free (P = 0.006) and overall survival (P = 0.03). These findings indicate that the presence of Foxp3+ tumor cells represents a new independent prognostic factor of improved outcome in HER2-overexpressing breast carcinoma, which could help identify high-risk patients for additional therapies after neoadjuvant chemotherapy.

Keywords

Foxp3HER2Breast cancerTumor cellsNeoadjuvant chemotherapy

Copyright information

© Springer Science+Business Media, LLC. 2010