Breast Cancer Research and Treatment

, Volume 121, Issue 2, pp 469–477

Meta-analysis of vitamin D, calcium and the prevention of breast cancer

Authors

  • Peizhan Chen
    • Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological SciencesChinese Academy of Sciences
    • Graduate School of the Chinese Academy of Sciences
  • Pingting Hu
    • Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological SciencesChinese Academy of Sciences
    • Graduate School of the Chinese Academy of Sciences
  • Dong Xie
    • Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological SciencesChinese Academy of Sciences
    • Graduate School of the Chinese Academy of Sciences
  • Ying Qin
    • Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological SciencesChinese Academy of Sciences
    • Graduate School of the Chinese Academy of Sciences
  • Fudi Wang
    • Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological SciencesChinese Academy of Sciences
    • Graduate School of the Chinese Academy of Sciences
    • Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological SciencesChinese Academy of Sciences
    • Graduate School of the Chinese Academy of Sciences
Epidemiology

DOI: 10.1007/s10549-009-0593-9

Cite this article as:
Chen, P., Hu, P., Xie, D. et al. Breast Cancer Res Treat (2010) 121: 469. doi:10.1007/s10549-009-0593-9

Abstract

Vitamin D and calcium intake have been suggested to have protective effects against breast cancer; however, the data have been inconclusive. The present meta-analysis examined the overall effects of vitamin D intake, circulating 25(OH)D and 1α,25(OH)2D levels, and calcium intake on breast cancer risk. Data from 11 studies on vitamin D intake, 7 studies on circulating 25(OH)D levels, 3 studies of circulating 1α,25(OH)2D levels, and 15 studies on calcium intake and breast cancer risk were included in this analysis. From the meta-analysis, there was a significant inverse relationship between vitamin D intake and breast cancer risk, with an overall relative risk (RR) of high versus low vitamin D intake for breast cancer of 0.91 (95% CI = 0.85–0.97). The highest quantile of circulating 25(OH)D was found to be associated with a 45% (OR = 0.55, 95% CI = 0.38–0.80) decrease in breast cancer when compared with the lowest quantile. No significant association for the circulating 1α,25(OH)2D level and breast cancer was found (OR = 0.99, 95% CI = 0.68–1.44). For calcium, a 19% (RR = 0.81, 95% CI = 0.72–0.90) decrease in breast cancer risk was found for those with highest quantile of calcium intake compared to the lowest quantile. These results provide strong evidence that vitamin D and calcium have a chemopreventive effect against breast cancer.

Keywords

Vitamin D25(OH)D1α,25(OH)2DCalciumBreast cancerMeta-analysis

Supplementary material

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Supplementary Table 1 Studies included in the comparison of the high versus low quantiles of vitamin D intake and breast cancer risk. (XLSM 13 kb)
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Supplementary material 2 (XLSM 15 kb)
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Supplementary material 3 (XLSM 14 kb)
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Supplementary Table 2Studies included for meta-analysis of circulating 25(OH)D levels and breast cancer risk. (XLSM 15 kb)
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Supplementary Table 3Studies included for meta-analysis of circulating 1α,25(OH)2D levels and breast cancer risk. (XLSM 12 kb)
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Supplementary Table 4Included studies of high versus low quantiles of calcium intake and breast cancer risk. (XLSM 14 kb)
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Supplementary material 7 (XLSM 15 kb)
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Supplementary material 8 (XLSM 16 kb)
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Supplementary material 9 (XLSM 14 kb)

Copyright information

© Springer Science+Business Media, LLC. 2009