Breast Cancer Research and Treatment

, Volume 118, Issue 3, pp 599–603

STK15 F31I polymorphism is associated with breast cancer risk: a meta-analysis involving 25,014 subjects

Authors

  • Li-Xin Qiu
    • Department of Medical Oncology, Cancer HospitalFudan University
    • Department of Oncology, Shanghai Medical CollegeFudan University
  • Bo Chen
    • Department of Geriatrics, First Affiliated HospitalNanjing Medical University
  • Chen Mao
    • Department of Epidemiology, School of Public Health and Tropical MedicineSouthern Medical University
  • Ping Zhan
    • Department of Respiratory MedicineNanjing Chest Hospital
  • Hui Yuan
    • Department of Epidemiology and Biostatistics, School of Public HealthAnhui Medical University
  • Kai Xue
    • Department of Medical Oncology, Cancer HospitalFudan University
    • Department of Oncology, Shanghai Medical CollegeFudan University
    • Department of Medical Oncology, Cancer HospitalFudan University
    • Department of Oncology, Shanghai Medical CollegeFudan University
    • Department of Medical Oncology, Cancer HospitalFudan University
    • Department of Oncology, Shanghai Medical CollegeFudan University
Epidemiology

DOI: 10.1007/s10549-009-0574-z

Cite this article as:
Qiu, L., Chen, B., Mao, C. et al. Breast Cancer Res Treat (2009) 118: 599. doi:10.1007/s10549-009-0574-z

Abstract

Published data on the association between STK15 F31I polymorphism and breast cancer risk are inconclusive. In order to derive a more precise estimation of the relationship, a meta-analysis was performed. Medline, PubMed, Embase, Web of Science, and Chinese Biomedicine Database were searched. Crude ORs with 95% CIs were used to assess the strength of association between the STK15 F31I polymorphism and breast cancer risk. The pooled ORs were performed for codominant model (FI vs. FF; II vs. FF), dominant model (FI + II vs. FF), and recessive model (II vs. FI + FF), respectively. A total of 10 studies including 10,537 cases and 14,477 controls were involved in this meta-analysis. Overall, significantly elevated breast cancer risk was associated with II variant genotype in homozygote comparison and recessive genetic model when all studies were pooled into the meta-analysis (for II vs. FF: OR = 1.23, 95% CI = 1.10–1.37; for recessive model: OR = 1.21, 95% CI = 1.05–1.40). In the subgroup analysis by ethnicity, significantly increased risks were found for II allele carriers among Caucasians (for II vs. FF: OR = 1.24, 95% CI = 1.08–1.43; for recessive model: OR = 1.21, 95% CI = 1.00–1.45); significantly increased risks were also found among Asians for II versus FF (OR = 1.21; 95% CI = 1.01–1.45). In conclusion, this meta-analysis suggests that the STK15 31II allele is a low-penetrant risk factor for developing breast cancer.

Keywords

STK15PolymorphismBreast cancerSusceptibilityMeta-analysis

Copyright information

© Springer Science+Business Media, LLC. 2009