Breast Cancer Research and Treatment

, Volume 118, Issue 3, pp 599–603

STK15 F31I polymorphism is associated with breast cancer risk: a meta-analysis involving 25,014 subjects


DOI: 10.1007/s10549-009-0574-z

Cite this article as:
Qiu, LX., Chen, B., Mao, C. et al. Breast Cancer Res Treat (2009) 118: 599. doi:10.1007/s10549-009-0574-z


Published data on the association between STK15 F31I polymorphism and breast cancer risk are inconclusive. In order to derive a more precise estimation of the relationship, a meta-analysis was performed. Medline, PubMed, Embase, Web of Science, and Chinese Biomedicine Database were searched. Crude ORs with 95% CIs were used to assess the strength of association between the STK15 F31I polymorphism and breast cancer risk. The pooled ORs were performed for codominant model (FI vs. FF; II vs. FF), dominant model (FI + II vs. FF), and recessive model (II vs. FI + FF), respectively. A total of 10 studies including 10,537 cases and 14,477 controls were involved in this meta-analysis. Overall, significantly elevated breast cancer risk was associated with II variant genotype in homozygote comparison and recessive genetic model when all studies were pooled into the meta-analysis (for II vs. FF: OR = 1.23, 95% CI = 1.10–1.37; for recessive model: OR = 1.21, 95% CI = 1.05–1.40). In the subgroup analysis by ethnicity, significantly increased risks were found for II allele carriers among Caucasians (for II vs. FF: OR = 1.24, 95% CI = 1.08–1.43; for recessive model: OR = 1.21, 95% CI = 1.00–1.45); significantly increased risks were also found among Asians for II versus FF (OR = 1.21; 95% CI = 1.01–1.45). In conclusion, this meta-analysis suggests that the STK15 31II allele is a low-penetrant risk factor for developing breast cancer.


STK15PolymorphismBreast cancerSusceptibilityMeta-analysis

Copyright information

© Springer Science+Business Media, LLC. 2009

Authors and Affiliations

  1. 1.Department of Medical Oncology, Cancer HospitalFudan UniversityShanghaiChina
  2. 2.Department of Oncology, Shanghai Medical CollegeFudan UniversityShanghaiChina
  3. 3.Department of Geriatrics, First Affiliated HospitalNanjing Medical UniversityNanjingChina
  4. 4.Department of Epidemiology, School of Public Health and Tropical MedicineSouthern Medical UniversityGuangzhouChina
  5. 5.Department of Respiratory MedicineNanjing Chest HospitalNanjingChina
  6. 6.Department of Epidemiology and Biostatistics, School of Public HealthAnhui Medical UniversityAnhuiChina