Epidemiology

Breast Cancer Research and Treatment

, Volume 120, Issue 2, pp 509-517

P53 codon 72 polymorphism contributes to breast cancer risk: a meta-analysis based on 39 case–control studies

  • Zhizhong ZhangAffiliated withKey Laboratory of Reproductive Medicine, Nanjing Medical UniversityDepartment of Molecular & Genetic Toxicology, School of Public Health, Nanjing Medical University
  • , Meilin WangAffiliated withKey Laboratory of Reproductive Medicine, Nanjing Medical UniversityDepartment of Molecular & Genetic Toxicology, School of Public Health, Nanjing Medical University
  • , Dongmei WuAffiliated withDepartment of Molecular & Genetic Toxicology, School of Public Health, Nanjing Medical University
  • , Miaomiao WangAffiliated withDepartment of Molecular & Genetic Toxicology, School of Public Health, Nanjing Medical University
  • , Na TongAffiliated withEpidemiology & Biostatistics, Cancer Center of Nanjing Medical University
  • , Yuanyuan TianAffiliated withDepartment of Molecular & Genetic Toxicology, School of Public Health, Nanjing Medical University
  • , Zhengdong ZhangAffiliated withKey Laboratory of Reproductive Medicine, Nanjing Medical UniversityDepartment of Molecular & Genetic Toxicology, School of Public Health, Nanjing Medical UniversityEpidemiology & Biostatistics, Cancer Center of Nanjing Medical University Email author 

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Abstract

P53 is a tumor suppressor gene and plays important roles in the etiology of breast cancer. Studies revealing conflicting results on the role of p53 codon 72 polymorphism (G>C) on breast cancer risk led us to perform a meta-analysis to investigate this relationship. Thirty-nine published studies, including 26,041 breast cancer cases and 29,679 controls were identified. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the associations. The overall results suggested that the variant genotypes were associated with a significantly reduced breast cancer risk (GC vs. GG: OR = 0.91, 95% CI: 0.83–1.00; CC/GC vs. GG: OR = 0.90, 95% CI: 0.82–0.99). In the stratified analyses, significantly decreased risks were also found among European populations (GC vs. GG: OR = 0.89, 95% CI: 0.80–0.99; CC/GC vs. GG: OR = 0.88, 95% CI: 0.80–0.98) and studies with population-based controls (GC vs. GG: OR = 0.88, 95% CI: 0.78–0.98; CC/GC vs. GG: OR = 0.87, 95% CI: 0.78–0.97). The results suggested that p53 codon 72 polymorphism may contribute to susceptibility to breast cancer, especially in Europeans. Additional well-designed large studies were required to validate this association in different populations.

Keywords

P53 Breast cancer Meta-analysis Molecular epidemiology Genetic variation